LCT与HPV联合筛查宫颈病变临床研究

Clinical study on LCT combined with HPV screening in diagnosis of cervical lesions

目的探讨薄层液基细胞学检查(LCT)与人乳头瘤病毒(HPV)检测联合筛查宫颈病变的临床价值。方法收集2016年5月—2017年5月在我院行宫颈癌筛查100例妇女的临床资料,以病理检查结果为金标准,分析LCT、HPV、LCT联合HPV诊断宫颈癌前病变阳性及阴性检出率、灵敏度、特异度。结果 100例受检者中经病理检查有58例为阳性,LCT检出真阳性例数为42例,HPV检出真阳性例数为32例,LCT联合HPV检出真阳性例数为55例,LCT联合HPV检测的灵敏度明显高于LCT、HPV单独检测,差异有统计学意义(P<0.05)。结论相对于单独使用LCT、HPV而言,LCT与HPV联合检测能有效提高宫颈病变诊断准确性,降低误诊和漏诊率,临床诊断价值较高。

Objective To investigate the liquid-based cytology test （LCT） combined with human papilloma virus （HPV） screening in diagnosis of cervical lesions. Methods The clinical data of 100 women with cervical cancer screening in our hospital from April 2016 to December 2016 were collected. The results of LCT, HPV, LCT combined with HPV and pathological examination were compared. The positive and negative detection rate, sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and Youden index of LCT, HPV, LCT combined with HPV in the diagnosis of cervical lesions were analyzed. Results Among 100 cases of patients, there were 58 positive cases detected by pathological examination, 42 true positive cases detected by LCT, 52 true positive cases detected by HPV, 55 true positive cases detected by LCT combined with HPV; The positive detection rate of LCT combined with HPV was higher than that of LCT or HPV （P〈0.05）. Conclusion Compared with pure application of LCT or HPV, LCT combined with HPV can effectively increase the diagnostic accuracy in cervical lesions, decrease the misdiagnosis and missed rate, which has higher clinical diagnostic value.