乳腺癌内分泌治疗预测因素的研究进展

Research Progress on Predictive Factors for Endocrine Therapy in Breast Cancer

内分泌治疗是雌激素受体(ER)阳性乳腺癌治疗的重要手段之一。临床研究显示,许多接受内分泌治疗的患者在治疗期间或治疗后发生复发,这些患者对内分泌治疗原发耐药或在治疗期间发生耐药。因此,有必要寻找可靠预测因子来预测哪些患者对内分泌治疗敏感。本文主要探讨临床病理因素、多基因检测及液体活检在乳腺癌内分泌治疗中的预测作用。

Endocrine therapy（ET） is an important treatment for ER-positive breast cancer.The clinical studies have shown that patients may relapse during or following completion of adjuvant ET,and have primary resistance or develop resistance to ET during treatment,so reliable indicators are needed for patients to predict the respond to ET.This article reviews the main research progress on predictive roles of clinicopathologic parameters,multigene tests and liquid biopsy in response to ET for patients with breast cancer.