丹红注射液联合针刺治疗血管性帕金森综合征临床研究

Clinical effect of Danhong injection combined with acupuncture in the treatment of vascular parkinson

目的 评价丹红注射液联合针刺治疗血管性帕金森综合征（vascular parkinsonism, VP）的疗效。方法 将符合入选标准的98例VP患者按随机数字表法分为2组，每组49例。对照组采用西医常规疗法治疗，观察组在对照组基础上加用丹红注射液及针刺治疗。2组均治疗8周。采用帕金森病综合评价量表进行运动功能评分，采用中医症状量表进行非运动功能评分；采用超声经颅多普勒血流分析仪检测脑血流动力学指标，采用全自动血液流变仪检测血浆黏度和纤维蛋白原含量，评价临床疗效。结果 观察组总有效率为87.8%（43/49）、对照组为71.4%（35/49），2组比较差异有统计学意义（χ2＝4.021，P＜0.05）。治疗后，观察组运动功能评分[（27.4±10.5）分比（32.8±8.2）分，t＝2.865]、非运动功能评分[（4.1±2.2）分比（9.8±4.0）分，t＝8.785]均低于对照组（P＜0.05）；血浆黏度[（1.49±0.21）mPa？s比（1.64±0.28）mPa？s，t＝3.000]、纤维蛋白原[（3.18±0.77）g/L比（3.86±0.70）g/L，t＝4.574]、阻力指数[（0.49±0.12）比（0.62±0.16），t＝4.550]均低于对照组（P＜0.05）；收缩期最大血流速度[（81.97±12.65）cm/s 比（74.39±9.48）cm/s，t＝3.357]、平均血流速度[（61.54±7.10）cm/s比（55.87±6.24）cm/s，t＝4.199]高于对照组（P＜0.05）。观察组不良反应发生率为14.3%（7/49）、对照组为16.3%（8/49），2组比较差异有统计学意义（χ2＝0.079，P＞0.05）。结论 丹红注射液结合针刺可改善VP患者临床症状及血液循环，提高疗效。

Objective To study the clinical effect of Danhong injection combined with acupuncture in the treatment of vascular Parkinson syndrome （VP）. Methods A total of 98 patients with VP who were treated in the hospital from January 2015 to January 2017 were enrolled in this study. According to the digital random table method, the patients were divided into two groups, the observation group and the control group with each 49 cases. Both groups were given basic treatment, and based on that, the observation group was treated with Danhong injection and acupuncture treatment. Both groups were compared before and after 8 weeks of treatment with the outcome indices of exercise and motor function score, blood rheology index and cerebral hemodynamic indexes, as well as adverse reactions. Results The total effective rate of the observation group was 87.76% （43/49）, while the control group was 71.43% （35/49）, and the difference was statistically significant （χ2=4.021, P〈0.05）. After treatment, the motor function score （27.4 ± 10.5 vs. 32.8 ± 8.2, t=2.865）, the scores of non-motor function （4.1 ± 2.2 vs. 9.8 ± 4.0, t=8.785） of the observation group were lower than those of the control group （P〈0.05）. After treatment, the plasma viscosity （1.49 ± 0.21 mPa？s vs. 1.64 ± 0.28 mPa？s, t=3.000）, fibrinogen （3.18 ± 0.77 g/L, vs. 3.86 ± 0.70 g/L, t=4.574）, and the RI index （0.49 ± 0.12 vs. 0.62 ± 0.16, t=4.550） of the observation group was significantly lower than those of the control group （P〈0.05）. The Vs （81.97 ± 12.65 cm/s vs. 74.39 ± 9.48 cm/s, t=3.357） and Vm （61.54 ± 7.10 cm/s vs. 55.87 ± 6.24 cm/s, t=4.199） of observation group was significantly higher than those of the control group（P〈0.05）. The total incidence of adverse reactions in the observation group was 14.29%, which was no significant difference compared with that of the control group of 16.33% （χ2=0.079, P〉0.05）. Conclusions The Danhong injection combined with acupuncture showed better effect on VP patients, and it could improve the clinical symptoms and blood circulation.