二仙补肾益精解毒方改善无症状性弱精子症患者精子活力临床研究

Clinical efficacy and safety of Erxian Bushen Yijing Jiedu decoction in improving sperm motility of asymptom asthenospermia

目的:评价二仙补肾益精解毒方改善无症状性弱精子症患者精子活力的临床疗效和安全性。方法:将72例无症状性弱精子症患者按随机对照的试验方法分成试验组和对照组,试验组用二仙补肾益精解毒方免煎颗粒每日1剂、早晚各半剂进行治疗,对照组用左卡尼汀口服液每次1支、每日2次进行治疗,疗程11周。整个疗程中治疗不中断,采用治疗前、治疗后对照研究的方法客观评价二仙补肾益精解毒方对无症状性弱精子症患者的疗效。重点观察无症状性弱精子症患者精液精子总活力(PR+NP)、前向运动精子百分率(PR)变化,同时注意对药物毒副作用的观察。结果:试验组精子总活力、前向运动精子百分率治疗前后比较采用配对t检验,差异均有显著统计学意义(P<0.01);对照组精子总活力、前向运动精子百分率治疗前后比较采用配对t检验,精子总活力的差异无统计学意义(P>0.05),前向运动精子百分率的差异有统计学意义(P<0.05);两组治疗后精子总活力、前向运动精子百分率,两组比较采用成组t检验,差异均有统计学意义(P<0.05);治疗前后精子总活力差值及前向运动精子百分率差值,两组比较采用成组t检验,其中精子总活力差值的差异均有统计学意义(P<0.05),前向运动精子百分率差值的差异具有显著统计学意义(P<0.01)。试验组显效、有效、无效例数分别为17、10、3例;对照组显效、有效、无效例数分别为10、9、10例。两组精子活力总体疗效比较采用Mann-Whitney U检验,差异具有统计学意义(P<0.05)。除对照组1例患者药物过敏,试验组1例患者失访外,两组患者在治疗过程中均未出现头晕、头痛、腹痛、腹泻、恶心、呕吐等明显的局部和全身不良反应。结论:采用二仙补肾益精解毒方治疗无症状性弱精子症安全有效。

Objectives： To observe the clinical efficacy and safety of Erxian Bushen Yijing decoction in improving sperm motility of asymptomatic asthenospermia. Methods： 72 patients with asymptomatic asthenospermia were randomly divided into treatment group and control group. Treatment group received Erxian Bushen Yijing Jiedu decoction granules one agent a day,semi-agent in the morning and evening for treatment,and the control group received L-carnitine oral solution one agent a day,semi-agent in the morning and evening for treatment. The treatment lasted 11 weeks without interruption. The curative effect of Erxian Bushen Yijing Jiedu decoction on patients with asymptomatic oligospermia was evaluated before and after treatment. The changes in sperm motility and motility of semen PR and（ PR ＋ NP） were observed,and side effects were observed. Results： The total sperm activity and percentage of forward spermatozoa between before and after treatment in treatment group had significant differences（ P 0. 01）. The sperm total activity before and after treatment in control group had no significant difference（ P 0. 05） and percentage of forward spermatozoa had significant difference（ P 0. 05）. The sperm total activity and percentage of forward spermatozoa after treatment in two groups had significant differences（ P 0. 05）. The difference in value of total sperm activity between before and after treatment in the two groups had significant difference（ P 0. 05） and difference in value of percentage of forward spermatozoa between before and after treatment in the two groups had significant difference（ P 0. 01）. The excellent,effective and ineffective cases in treatment group were 17,10 and 3. The excellent,effective and ineffective cases in control group were 10,9 and 10 cases respectively. The difference in overall efficacy of sperm motility between the two groups was statistically significant（ P 0. 05）. There were no significant local and systemic adverse reactions such as dizziness,headache,abdominal pain,diarrhea,nausea and vomiting during the treatment of the patients in treatment group and control group,except a patient with drug allergy in control group and a patient lost follow-up in treatment group. Conclusion： The use of Erxian Bushen Yijing Decoction in the treatment of asymptomatic asthenospermia has a good effect.