外源基因治疗肿瘤研究进展

The research status of exogenous gene treatment tumor mechanism

肿瘤的发生和发展涉及单个或多个基因的改变。肿瘤的基因治疗已成为新的发展方向。外源基因治疗肿瘤的研究集中在以下3个方面:1)通过转入自杀基因引起肿瘤细胞表型的改变,从而引起药物对肿瘤细胞直接或间接杀伤作用;2)通过转入外源的小分子RNA干扰沉默肿瘤细胞中突变基因的表达;3)通过外源基因的引入增强药物化疗效果。本文就这3个方面的治疗机制及研究现状进行阐述。

The occurrence and development of tumor refer to single or multiple genetic changes. Gene therapy has become a new research direction. Exogenous gene therapy of tumor research focused on the following three aspects: suicide gene causing change in the phenotype of tumor cells,resulting in drug directly or killing tumor cells indirectly; small RNA interference and silence mutated gene expression in tumor cells; exogenous gene enhancing the effect of chemotherapy drugs. We will elaborate the mechanism and research status of these three aspects in the paper.