摘要
目的了解肿瘤患者医院感染铜绿假单胞菌的临床分布及对常用抗菌药物的耐药性,为临床合理使用抗生素提供参考依据。方法对我院2015年1月~2016年12月收治的恶性肿瘤患者临床标本中分离出的189株铜绿假单胞菌的分布及耐药性进行回顾性分析。结果 189株铜绿假单胞菌中,79.9%(151/189)来自呼吸道;其主要分布在综合内科、化疗科、放疗科及ICU等科室,分别占23.81%、17.46%、15.87%和12.17%。铜绿假单胞菌对氨曲南、头孢他啶和哌拉西林耐药率最高,分别为50.79%、32.28%和30.69%,对碳青霉烯类亚胺培南和美罗培南的耐药率分别为23.81%和20.11%,对哌拉西林/他唑巴坦和头孢吡肟耐药率最低分别为15.34%和18.52%。结论肿瘤患者医院感染铜绿假单胞菌以综合内科、化疗科、放疗科及ICU为主,对氨曲南、头孢他啶和哌拉西林的耐药率均在30%以上。临床微生物实验室应加强对铜绿假单胞菌耐药性监测,同时根据药敏结果合理选用抗菌药物以减缓耐药菌株的产生。
Objective To investigate the distribution of infection sites and changes of antimicrobial resistance of Pseudomonas aeruginosa(PAE)isolated from infective specimens in our tumor hospital,so as to provide evidence for clinical use of antimicrobial agents. Methods Infective specimens were collected from different infected sites of patients admitted and treated during Jan.2015 to Dec.2016;189 strains of PAE were isolated,their distribution and resistance were retrospectively analyzed. Results The isolated 189 PAE were mainly from respiratory tract specimens(151/189,79.9%).They were distributed mainly in general medicine,medical oncology,radiotherapy department and ICU,accounting for 23.81%,17.46%,15.87% and 12.17%,respectively.The drug resistance rates of PAE were the most higher to aztreonam,ceftazidime and piperacillin,accounting for 50.79%,32.28% and30.69%,respectively;to imipenem and meropenem,accounting for 23.81% and 20.11%,respectively;the drug resistance rates of PAE were the most lower to piperacillin/Tazobactam and cefepime,accounting for 15.34% and18.52%,respectively. Conclusion Patients with tumor infected in hospital with PAE were mainly from general medicine,medical oncology,radiotherapy department and ICU.The drug resistance rates of PAE were greater than30%to aztreonam,ceftazidime and piperacillin.Clinical microbiology laboratory should strengthen the monitoring of drug resistance of PAE.and use reasonably antibiotics.Antimicrobial agents should be selected according to drug sensitivity test to reduce the production of drug resistant strains.
出处
《蛇志》
2017年第4期398-400,共3页
Journal of Snake
基金
广西卫计委科研立项项目(No.Z2015574)
广西卫计委科研立项项目(No.Z2015598)
广西卫计委科研立项项目(No.Z2015619)
关键词
肿瘤患者
医院感染
铜绿假单胞菌
耐药性
Patients with tumor
Nosocomial infection
Pseudomonas aeruginosa(PAE)
Drug resistance