子宫内膜癌组织中CA125和EpCAM的表达及与临床特征的关系

Expression of CA125 and EpCAM in endometrial carcinoma and its relationship with clinical features

目的:探讨子宫内膜癌组织中CA125和EpCAM的表达及与临床特征的关系。方法:选取本院2015年1月至2017年1月行手术治疗的45例子宫内膜癌患者标本,同时选取同期子宫内膜增生病例标本30例及正常子宫内膜标本10例作为对照研究。采用免疫组化学染色法检测子宫内膜病变组织中CA125及EpCAM表达情况,分析CA125及EpCAM的表达与子宫内膜癌患者临床病理特征的关系。结果:正常对照组、子宫内膜增生组及子宫内膜癌组3组间CA125及EpCAM阳性表达率比较差异有统计学意义(P1=0.002,P2=0.006)。CA125及EpCAM在子宫内膜高组织分化程度、肌层侵袭深度≥1/2及FIGO分期Ⅲ-Ⅳ期患者中的阳性表达率均明显高于中低组织分化程度、肌层侵袭深度<1/2及FIGO分期Ⅰ-Ⅱ期患者(P<0.05)。CA125及EpCAM的阳性表达率在不同年龄患者、不同淋巴转移情况等临床特征中比较无显著性差异(P>0.05)。CA125与EpCAM的表达呈现正相关性(r=0.297,P=0.011)。结论:CA125和EpCAM的表达与子宫内膜病变进展有关,临床可通过监测患者癌组织中CA125和EpCAM的表达情况,对判定患者癌病进展及预后有一定的指导意义。

Objective: To investigate the expression of CA125 and EpCAM in endometrial carcinoma and its relationship with clinical features.Methods: A total of 45 patients with endometrial carcinoma who underwent surgical treatment in our hospital from January 2015 to January 2017 were selected.At the same time,30 cases of endometrial hyperplasia and 10 cases of normal endometrium were selected as control study.Immunohistochemical staining method was used to detect the expression of CA125 and EpCAM in endometrial lesions,and to analyze the relationship between the expression of CA125 and EpCAM and the clinicopathological features of endometrial carcinoma.Results: The positive expression rates of CA125 and EpCAM in the normal control group,endometrial hyperplasia group and endometrial carcinoma group were significantly different(P1 = 0.002,P2 = 0.006).CA125 and EpCAM in endometrial tissue of high differentiation,muscular layer invasion depth more than 1/2 positive expression and FIGO stage III-IV stage patients were significantly higher than the low rate of tissue differentiation,myometrial invasion depth < 1/2 and FIGO stage I-II patients(P <0.05).In patients with different age and lymphatic metastasis,there was no significant difference in the positive expression rates of CA125 and EpCAM(P > 0.05).The expression of CA125 was positively correlated with the expression of EpCAM(r = 0.297,P =0.011).Conclusion: The expression of CA125 and EpCAM is related to the progression of endometrial lesions,by monitoring the expression of CA125 and EpCAM in patients with cancer,it has certain guiding significance for the diagnosis of cancer progression and prognosis.