腹膜透析患者血浆白蛋白水平对残余肾功能的影响

Influence of plasma albumin level on residual renal function in peritoneal dialysis patients

目的:探讨腹膜透析(peritoneal dialysis,PD)患者血浆白蛋白(albumin,ALB)水平对残余肾功能(residual renal function,RRF)的影响。方法:选择72例PD患者为研究对象,对患者进行为期12个月的随访,监测RRF、血浆ALB、hs-CRP的变化,以24 h尿量≤400 m L为随访终点。结果:终点事件组患者与无终点事件组相比,血浆ALB明显降低,hs-CRP水平明显升高,差异有统计学意义(P<0.05);血浆ALB改变值>1.52 g/L组RRF明显低于<1.52 g/L组,hs-CRP水平则明显高于后者,差异均有统计学意义(P<0.05)。结论:血浆白蛋白在PD患者残余肾功能下降中起到保护作用。

Objective: To investigate the influence of plasma albumin(ALB) level on residual renal function(RRF) in peritoneal dialysis patients.Methods: 72 cases of patients with PD were selected as the research object,for a period of 12 months of followup,RRF,the changes of plasma ALB and hs-CRP were monitored,24 h in urine ≤ 400 m L was the follow-up end point.Results: The plasma ALB in end point events group was lower than that without end point events group,hs-CRP level increased significantly,the difference was statistically significant(P < 0.05).RRF in plasma ALB change > 1.52 g/L group was significantly lower than that of ALB change < 1.52 g/L group,and hs-CRP was significantly higher,the difference was of statistically significant(P < 0.05).Conclusion: Plasma ALB plays a protective role in the decreasing of RRF in patients with PD.