外阴鳞癌治疗进展

Advances in the Treatment of Vulvar Squamous Cell

外阴癌约占女性生殖道恶性肿瘤3%~5%,其中以鳞状细胞癌(鳞癌)最常见。其多发于绝经后女性,且随年龄的增加发病率有上升趋势。外阴鳞癌的早期症状并不特异,晚期可出现瘙痒、疼痛、刺激和分泌物增多等症状,从而延误诊断和治疗。目前其诊断方式仍依靠活检,对于无症状可疑者进行活检也是必要的。对于早期外阴鳞癌的治疗多采取手术切除,晚期则采用放化疗、靶向治疗等综合治疗,但因该病较少见,尚未建立一套标准治疗方案。近年来,对于外阴鳞癌在手术、放疗、新辅助化疗、靶向治疗等领域均有新的进展,故就外阴鳞癌的治疗进展进行综述,可为后续治疗提供参考。

Vulvar cancer account for 3% to 5% of all female genital cancers. The commonest histological type is squamous cell carcinoma of the vulva. It is frequently found in postmenopausal women and increases with age. The early symptoms of squamous cell carcinoma of the vulva are not specific, and late symptoms of pruritus, pain, irritation and increased secretions can delay diagnosis and treatment. At present, the diagnosis is still based on biopsy, and biopsy of asymptomatic suspects is also necessary. For the treatment of early stage of squamous cell carcinoma of the vulva, surgical resection is usually performed, and radiotherapy, chemotherapy and targeted therapy are adopted in the later stage, because of the low morbidity, a standard treatment regimen has not been established. In recent years, there have been new progresses in surgery, radiotherapy,chemotherapy and other fields for vulvar squamous cell carcinoma. So this article gives an overview on treatment of vulvar squamous carcinoma so as to provide reference for this disease.