TXNIP介导的氧化应激在疾病中的作用机制

Action and mechanism of oxidative stress mediated by TXNIP in diseases

硫氧还蛋白相互作用蛋白(TXNIP)通过与硫氧还蛋白(Trx)的结合而抑制Trx的抗氧化作用,促进了活性氧簇(ROS)的产生与积聚,诱发内质网应激与线粒体应激,最终可诱导炎症或细胞凋亡。TXNIP所介导的氧化应激在糖尿病及其并发症(糖尿病肾病、糖尿病视网膜病变等)、动脉粥样硬化、缺血/再灌注损伤、癌症(肝细胞癌、膀胱癌、乳腺癌、白血病)等疾病的发生、发展过程中起着重要的调控作用。该文就TXNIP介导的氧化应激在相关疾病中的作用机制及研究进展进行综述。

Thioredoxin-interacting protein( TXNIP) suppresses the antioxidative function of thioredoxin( Trx) by combining with thioredoxin( Trx). Therefore,it promotes the generation and accumulation of reactive oxygen species( ROS),inducing endoplasmic reticulum stress and mitochondrial stress,which leads to cellular inflammation or cellular apoptosis ultimately.TXNIP-mediated oxidative stress plays a crucial role in controlling the generation and development of some diseases,such as diabetes and its complications( diabetic nephropathy diabetic retinopathy etc.),atherosclerosis ischemia/reperfusion injury,cancers( hepatocellular carcinoma,carcinoma of urinary bladder,mammary cancer,leukemia) etc. Here,we try to review the action and mechanism of oxidative stress mediated by TXNIP in the diseases and the progress in research.