纱条联合水囊填塞对前置胎盘并发产后出血患者凝血功能、RAS系统、应激反应的影响

Effect of gauze combined with water bag packing on the coagulation function,RAS system and stress response of patients with placenta previa complicated with postpartum hemorrhage

目的:研究纱条联合水囊填塞对前置胎盘并发产后出血患者凝血功能、RAS系统、应激反应的影响。方法:选择在本院接受治疗的69例前置胎盘并发产后出血患者,随机分为接受纱条联合水囊填塞的研究组、接受纱条填塞的对照A组、接受水囊填塞的对照B组。分娩后12小时,测定凝血功能指标、RAS系统指标、应激反应指标。结果:研究组分娩后12小时D-D、FDP、REN、AT-II、ALD、NE、E、MDA、ET-1的含量以及APTT、TT、PT的水平低于对照A组和对照B组,对照A组患者D-D、FDP、REN、AT-II、ALD、NE、E、MDA、ET-1的含量以及APTT、TT、PT的水平与对照B组比较无显著性差异。结论:纱条联合水囊填塞用于前置胎盘并发产后出血的治疗能够改善凝血功能并抑制RAS系统、应激反应的过度激活。

Objective：To study the effect of gauze combined with water bag packing on the coagulation function,RAS system and stress response of patients with placenta previa complicated with postpartum hemorrhage.Methods：69 patients with placenta previa complicated with postpartum hemorrhage who were treated in the hospital between March 2013 and September 2016 were selected and randomly divided into the research group who accepted gauze combined with water bag packing,the control group A who accepted gauze packing and the control group B who accepted water bag packing.The coagulation function indexes,RAS system indexes and stress response indexes were measured 12 hours after delivery.Results：D-D,FDP,REN,AT-II,ALD,NE,E,MDA and ET-1 contents as well as APTT,TT and PT levels of research group 12 hours after delivery were lower than those of control group A and control group B,and D-D,FDP,REN,AT-II,ALD,NE,E,MDA and ET-1 contents as well as APTT,TT and PT levels of control group A were not significantly different from those of control group B.Conclusion：Gauze combined with water bag packing for placenta previa complicated with postpartum hemorrhage can improve the coagulation function and inhibit the excessive activation of RAS system and stress response.