早期肠内营养干预对高血压脑出血患者神经功能、全身氧化应激及炎症反应的影响

Effect of early enteral nutrition intervention on nerve function,systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage

目的:探讨早期肠内营养干预对高血压脑出血患者神经功能、全身氧化应激及炎症反应的影响。方法:选择在本院接受住院治疗的高血压脑出血患者98例,随机分为对照组、观察组各49例。对照组接受常规肠外营养干预、观察组接受早期肠内营养干预。对比两组患者干预前后,血清中神经功能相关指标、氧化应激指标、炎症介质含量的差异。结果:干预前,两组血清中神经功能相关指标、氧化应激指标、炎症介质含量的差异无统计学意义。干预1周后,两组血清中S100B、NSE、GFAP、MBP、LPO、MDA、PCT、IL-1β、IL-6、TNF-α的含量低于干预前,GSH-PX的含量高于干预前且观察组血清中S100B、NSE、GFAP、MBP、LPO、MDA、PCT、IL-1β、IL-6、TNF-α的含量低于对照组,GSH-PX的含量高于对照组。结论:高血压脑出血患者接受早期肠内营养干预,可有效优化神经功能,并抑制全身氧化应激及炎症反应。

Objective：To study the effect of early enteral nutrition intervention on nerve function,systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage.Methods：A total of 98 patients with hypertensive cerebral hemorrhage who received hospitalization in the hospital between April 2015 and February 2017 were collected and divided into control group and observation group by random number table method,49 cases in each group.Control group received routine enteral nutrition intervention and observation group received early enteral nutrition intervention.The differences in serum levels of nerve function-related indexes,oxidative stress indexes and inflammatory mediators were compared between the two groups of patients before and after intervention.Results：Before intervention,the differences in serum levels of nerve function-related indexes,oxidative stress indexes and inflammatory mediators were not statistically significant between the two groups of patients.After 1 week of intervention,serum S100B,NSE,GFAP,MBP,LPO,MDA,PCT,IL-1β,IL-6 and TNF-αlevels of both groups of patients were lower than those before intervention while GSH-PX levels were higher than those before intervention,and serum S100B,NSE,GFAP,MBP,LPO,MDA,PCT,IL-1β,IL-6 and TNF-αlevels of observation group were lower than those of control group while GSH-PX level was higher than that of control group.Conclusion：Early enteral nutrition intervention can effectively optimize the nerve function and suppress the systemic oxidative stress and inflammatory response in patients with hypertensive cerebral hemorrhage.