尿激酶联合颅内微创血肿清除术对高血压性脑出血患者SP、SF、炎性因子及血管内皮功能的影响

Effect of urokinase combined with minimally invasive intracranial hematoma evacuation on serum ferritin,serum P substance,inflammatory factors and vascular endothelial function in patients with hypertensive intracerebral hemorrhage

目的:研究尿激酶联合颅内微创血肿清除术对高血压脑出血(HICH)患者血清P物质(SP)、血清铁蛋白(SF)、炎性因子及血管内皮功能的影响。方法:将本院收治的120例高血压性脑出血患者随机分为两组(对照组和观察组各60例)。对照组采用常规内科保守的方法,观察组在对照组治疗基础上接受尿激酶联合颅内微创血肿清除术。比较两组治疗前后血清SP、SF、炎性因子及血管内皮功能水平的变化。结果:治疗前,两组SP、SF、NO、ET-1、hs-CRP、IL-6、TNF-ɑ水平比较,差异不显著(P>0.05);两组治疗后,hs-CRP、IL-6、TNF-α、SF、ET-1、水平与本组治疗前相比均明显降低,其中观察组治疗后的hs-CRP、IL-6、TNF-α、SF、ET-1水平较对照组治疗后明显降低,差异比较均有显著性(P<0.05);治疗后两组SP、NO水平与治疗前相比明显升高(P<0.05),且观察组治疗后的SP、NO水平明显较对照组治疗后增高,差异比较均有显著性(P<0.05)。结论:对高血压脑出血患者行尿激酶联合微创颅内血肿清除术治疗,有助于改善患者SP、SF、炎性因子水平及血管内皮功能,能降低颅内压、缓解脑水肿,提高治疗效果。

Objective：To investigate the effects of minimally invasive evacuation of intracranial hematoma on serum SP,SF,vascular endothelial function and inflammatory factors of patients with hypertensive intracerebral hemorrhage.Methods：According to random data table method,a total of 120 patients with hypertensive cerebral hemorrhage from September 2016 to May 2017 were divided into observation group and the control group,60 cases in each group.The control group were treated with conventional treatment;on the basis of conventional treatment,the observation group underwent minimally invasive evacuation of intracranial hematoma.The levels of serum SF,SP,vascular endothelial function and inflammatory factors changes were compared between the two groups before and after the treatment.Results：Before treatment,the levels of serum SP、SF、NO、ET-1、hs-CRP、IL-6、TNF-αin the two groups were not statistically significant（P〉0.05）.The levels of hs-CRP、IL-6、TNF-α、SF、ET-1 after treatment in two groups were significantly lower than those in the same group before treatment（P〈0.05）,and the observation group levels were significantly lower than those in the control group;the levels of SP,NO in the two groups after treatment were significantly higher than before treatment（P〈0.05）,and the observation group was higher than that the control group with significant difference（P〈0.05）.Conclusion：The minimally invasive evacuation of intracranial hematoma can effectively improve the levels of SP,SF,inflammatory factors and vascular endothelial function,thus alleviate the brain edema and reduce the intracranial pressure of hypertensive intracerebral hemorrhage.