多维度模式康复对精神分裂症患者神经营养状态及炎症反应-细胞凋亡机制的影响

Effect of multidimensional rehabilitation on the neurotrophy state and inflammatory response-apoptosis mechanism in patients with schizophrenia

目的:研究多维度模式康复对精神分裂症患者神经营养状态及炎症反应-细胞凋亡机制的影响。方法:选择在四川大学华西医院就诊的精神分裂症患者并随机分为两组,多维度组接受多维度模式康复治疗,常规组接受常规康复治疗。治疗前及治疗后6个月,测定血清中神经营养指标、炎症反应指标、凋亡分子的含量以及外周血中凋亡分子的表达量。结果:康复治疗后6个月,两组患者血清中NGF、BDNF、IGF-1、IGF-2的含量均高于康复治疗前,血清中sTNFR1、sTNFR2、TNF-α、IL-1β、FasL、Fas、Caspase-3的含量以及外周血中FasL、Fas、Caspase-3的表达量均低于康复治疗前且多维度组患者血清中NGF、BDNF、IGF-1、IGF-2的含量高于常规组,血清中sTNFR1、sTNFR2、TNF-α、IL-1β、FasL、Fas、Caspase-3的含量以及外周血中FasL、Fas、Caspase-3的表达量低于常规组。结论:多维度模式康复用于精神分裂症能够改善神经营养状态、抑制神经细胞的炎症反应及细胞凋亡。

Objective：To study the effect of multidimensional rehabilitation on the neurotrophy state and inflammatory response-apoptosis mechanism in patients with schizophrenia.Methods：Patients with schizophrenia who were treated in West China Hospital,Sichuan University between February 2015 and April 2016 were selected and randomly divided into two groups,the multidimensional group received multidimensional rehabilitation therapy,and the conventional group received conventional rehabilitation therapy.The levels of neurotrophy indexes,inflammatory response indexes and apoptosis molecules in serum as well as the expression of apoptosis molecules in peripheral blood were measured before treatment and 6 months after treatment.Results：6 months after rehabilitation,serum NGF,BDNF,IGF-1 and IGF-2 levels of both groups of patients were higher than those before rehabilitation while serum sTNFR1,sTNFR2,TNF-α,IL-1β,FasL,Fas and Caspase-3 levels as well as peripheral blood FasL,Fas and Caspase-3 expression were lower than those before rehabilitation,and serum NGF,BDNF,IGF-1 and IGF-2 levels of multidimensional group were higher than those of conventional group while serum sTNFR1,sTNFR2,TNF-α,IL-1β,FasL,Fas and Caspase-3 levels as well as peripheral blood FasL,Fas and Caspase-3 expression were lower than those of conventional group.Conclusion：Multidimensional rehabilitation for schizophrenia can improve the neurotrophy state,and inhibit the inflammatory response and apoptosis of nerve cells.