普罗布考辅助视网膜光凝治疗对增殖早期糖尿病视网膜病变的视觉功能及血清生化指标的影响

The influence of probucol-assisted retinal photocoagulation therapy on the visual performance and serum biochemical indexes in patients with early proliferative diabetic retinopathy

目的:探讨普罗布考辅助视网膜光凝治疗对增殖早期糖尿病视网膜病变的视觉功能及血清生化指标的影响。方法:2014年12月~2017年5月在本院接受治疗的增殖早期DR患者170例,回顾治疗方案并分为接受单纯视网膜光凝治疗的对照组107例、接受普罗布考辅助视网膜光凝治疗的普罗布考组63例。治疗前及治疗6周后,对比两组患者视觉功能指标及血清血管新生指标、炎症介质、氧化应激指标含量的差异。结果:治疗前,两组患者的视觉功能指标水平,血清血管新生指标、炎症介质、氧化应激指标含量的差异无统计学意义。治疗6周后,普罗布考组平均视力、30°视敏度、30°~60°视敏度高于对照组;血清中血管新生指标HIF-1、VEGF、Ang-2的含量低于对照组;血清中炎症介质ICAM-1、IL-2、IL-23、TNF-α的含量低于对照组;血清中氧化应激指标MDA的含量低于对照组,TAC的含量高于对照组。结论:增殖早期DR患者接受普罗布考辅助视网膜光凝治疗,可有效优化视觉功能并促使机体内环境稳态恢复。

Objective:To explore the influence of probucol-assisted retinal photocoagulation therapy on the visual performance and serum biochemical indexes in patients with early proliferative diabetic retinopathy.Methods:170 patients with early proliferative DR who were treated in the hospital between December 2014 and May 2017 were retrospectively analyzed and divided into the control group(n=107)who received retinal photocoagulation therapy alone and the probucol group(n=63)who received probucol-assisted retinal photocoagulation therapy.The differences in the contents of visual performance indexes as well as serum angiogenesis indexes,inflammatory mediators and oxidative stress indexes were compared between the two groups before treatment and after 6 weeks of treatment.Results:Before treatment,the differences in the levels of visual performance indexes as well as serum contents of angiogenesis indexes,inflammatory mediators and oxidative stress indexes were not statistically significant between the two groups of patients.After 6 weeks of treatment,mean vision,30° visual acuity and30°~60° visual acuity of probucol group were higher than those of control group;serum angiogenesis indexes HIF-1,VEGF and Ang-2 contents were lower than those of control group;serum inflammatory mediators ICAM-1,IL-2,IL-23 and TNF-αcontents were lower than those of control group;serum oxidative stress index MDA content was lower than that of control group whereas TAC content was higher than that of control group.Conclusions:Probucol-assisted retinal photocoagulation therapy can effectively optimize the visual performance and promote the homeostasis recovery in patients with early proliferative diabetic retinopathy.