安宫牛黄丸对新生儿HIE患儿血清S-100B浓度的影响

Effect of Angong Niuhuang Pill on Serum S-100B Concentration of HIE in Newborn

目的:明确安宫牛黄丸对HIE(缺氧缺血性脑病)的治疗作用是否与S-100B的含量有关。方法:选取2015年1月至2016年1月赣州市人民医院收治的新生儿缺氧缺血性脑病患儿60例,随机分为常规组和治疗组(安宫牛黄丸组),各30例。常规组给予吸收氧气,纠正酸中毒、控制血压、控制血糖,补充液体和维持电解质及酸碱平衡等常规治疗;治疗组在常规组的基础上加用安宫牛黄丸治疗。比较两组患者血清S-100B水平并评价临床疗效。结果:安宫牛黄丸组血清S-100B蛋白水平为1.168±0.632,显著低于常规组的3.998±1.953,两组比较差异有统计学意义(P<0.05),说明安宫牛黄丸对HIE的治疗效果明显。结论:安宫牛黄丸对HIE的治疗作用与S-100B蛋白的含量有关,其在新生儿HIE患儿中的效果显著,值得临床推广应用。

Objective: To determine whether the therapeutic effect of Angong Niuhuang Pill on HIE is related to the content of S-100 B. Methods: 60 children with hypoxic-ischemic encephalopathy were treated in Ganzhou People's Hospital from January 2015 to January 2016. They were randomly divided into the routine group and the treatment group( Angong Niuhuang Pill group),each with 30 cases. The conventional group was given oxygen,acidosis,blood pressure control,blood glucose control,fluid and maintain electrolyte and acid-base balance and other conventional treatment; The treatment group was treated with Angong Niuhuang pills on the basis of routine group; The concentrations of serum S-100 B the clinical efficacy was evaluated. Results: The level of serum S-100 B protein was 1. 168 ± 0. 632 in the Angong Niuhuang Pill Group,significantly lower than 3. 998 ± 1. 953 in the conventional group,and the difference between the two groups was statistically significant( P < 0. 05). Conclusions: The content of Angong Niuhuang pill treatment effect on HIE and S-100 B protein and its effect on neonatal is significant,it is worthy of clinical application.