新型氯尼达明脂质体的制备及性质研究

Study on Preparation and Property of New Lonidamine Liposomes

采用安全性高的溶剂如丙二醇和聚乙二醇以及研磨法这一制备方法,先制成前体脂质体,再水合形成脂质体,即得新型氯尼达明脂质体。制得的氯尼达明脂质体粒径约160 nm,并且较为均一;采用反透析法测得包封率为86.12%;体外释放结果显示具有一定的缓释性。本研究中制备氯尼达明脂质体的制备工艺相对简便,有利于工业生产,且包封率及稳定性较好,将能较好地提高氯尼达明的生物利用度。

The new Lonidamine liposomes was prepared by the grinding method in mixed solution of propylene glycol and polyethylene glycol,and then hydrated to form liposomes. The particle size of Lonidamine liposomes was about 160 nm and the size distribution was uniform. The entrapment efficiency was 86. 12% and in vitro drug release was sustained release. The preparation technology of Lonidamine liposomes was simple,and suitable for industrial production. The new Lonidamine liposomes would improve bioavailability of Lonidamine.