脐血输注合并血浆置换治疗慢性重型肝炎的疗效初探

Therapeutic effect of umbilical cord blood transfusion combined with plasma exchange on chronic severe hepatitis

目的 :探讨脐血输注 (UCBT)合并血浆置换 (PE)治疗重型病毒性肝炎的效果。方法 :将 117例慢性重肝病人分为 4组 ,分别应用成人鲜血或冰冻新鲜血浆 (对照组 ) ,UCBT ,PE和UCBT +PE治疗 ,观察病人治疗前后部分肝功能指标及免疫功能指标的变化。结果 :各治疗组病人降低血胆红素、升高白蛋白、凝血酶原活动度、活性T淋巴细胞、CD4细胞、白细胞介素 2及膜白细胞介素 2受体的效果均优于对照组 ,其中UCBT +PE组的效果又优于其它各组。结论 :UCBT合并PE治疗能提高重型肝炎的治疗效果。

Objective To evaluate plasma exchange (PE) combined with umbilical cord blood transfusion (UCBT) in the treatment of chronic severe hepatitis. Methods One hundred and seventeen patients with chronic severe viral hepatitis were divided into four groups. The patients were treated with UCBT, PE or UCBT combined with PE respectively in the observed groups and treated with adult plasma transfusion in the control group. The liver function and immune function were determined in all patients before and after the treatment. Results The effects of reducing serum concentration of BIL and increasing serum albumin, PTA, IL2,mIL2 R,T Lymphocytes and CD4 lymphocytes in the observed groups were much better than those in the control group. The patients treated with UCBT combined with PE had the best outcome. Conclusion The therapeutic effects of UCBT combined with PE are much better than those of sole PE or sole UCBT. UCBT combined with PE is a reliable therapy for severe hepatitis.