宫颈癌患者临床病理特征与螺旋CT灌注成像的相关性

Correlation between clinicopathological characteristics and multislice spiral CT perfusion imaging in cervical cancer patients

目的探讨螺旋CT灌注成像(MSCT)与宫颈癌患者临床病理特征的相关性。方法运用随机数字法选取于江门市妇幼保健院诊治的宫颈癌患者60例作为研究对象,所有患者均进行CT灌注扫描,得出血流量(BF)、血容量(BV)、达峰时间(TTP)等灌注参数值,灌注参数与临床病理特征间的关系进行亚组趋势检验。结果经亚组趋势分析结果显示,年龄>50岁患者BF、BV水平明显高于年龄≤50岁者,差异有统计学意义(均P<0.05),BF水平随着病理分期提高而降低,原位癌组与Ⅰ期组BF水平明显高于Ⅱ、Ⅲ期组,差异有统计学意义(P<0.05),有脉管内瘤栓组以及淋巴结转移阳性组BF水平明显低于无脉管内瘤栓组以及淋巴结转移阴性组,差异有统计学意义(均P<0.05)。BF、BV水平随分化程度的降低而减低,低分化组显著低于中、高分化组,差异有统计学意义(均P<0.05)。结论 MSCT灌注参数BF、BV和临床分期、淋巴结转移、分化程度病理特征具有相关性,在病情发展的预测方面效果良好,具有一定的参考价值。

Objective To explore the correlation between clinicopathological characteristics and multislice spiral CT （MSCT） perfusion imaging in cervical cancer patients.Methods Sixty patients with cervical cancer treated in Jiangmen Maternal and Child Health Care Hospital were selected according to random number table.MSCT perfusion scan was performed,perfusion parameters were obtained,including blood flow （BF）,blood volume （BV）,time to peak （TⅠP）,and so on.The relationships between perfusion parameters and clinicopathological characteristics were analyzed by subgroup trend test.Results The results of subgroup trend test showed that the levels of BF and BV in patients over 50 years old were statistically significantly higher than those in patients less than or equal to 50 years old （P〈0.05） BF level decreased with increase of pathological stages.The levels of BF in patients with cervical carcinoma in situ and cervical cancer of stage Ⅰ were statistically significantly higher than those in patients with cervical cancer of stage Ⅱ and Ⅲ （P〈0.05）.The levels of BF in patients with vessel tumor emboli and lymph node metastasis were statistically significantly lower than those in patients without vessel tumor emboli and lymph node metastasis （P〈0.05）.The levels of BF and BV decreased with the decrease of differentiation degree.The levels of BF and BV in low differentiation group were statistically significantly lower than those in middle differentiation group and high differentiation group （P〈0.05）.Conclusion MSCT perfusion parameters （BF and BV） are correlated with clinicopathological characteristics （clinical stages,lymph node metastasis,differentiation degree） of cervical cancer patients.It has a good reference value in prediction of disease development.