43例口腔癌平阳霉素术前化疗效果相关因素分析

Correlation analysis of the chemotherapeutic effect of pingyangmycin on 43 patients with oral squamous cell carcinoma

目的 :通过对平阳霉素术前化疗效果的相关因素分析 ,早期判断平阳霉素对口腔鳞癌的效果 ,为确定进一步治疗方案提供指导。方法 :对本院近 3年来接受平阳霉素 (总量为 80mg)化疗的 4 3例口腔癌患者进行直线相关和回归分析 ,观察化疗期间体温改变、发热持续时间、胃肠道反应时间及WBC改变与疗效的关系。结果 :①接受平阳霉素化疗有效的患者多在第 3～ 6天出现局部反应 ;②发热的程度及胃肠道反应与化疗效果密切相关 (P<0 .0 5 )。结论 :化疗早期出现的发热、胃肠道症状及局部反应可以作为早期判断预期疗效的方法。

Objective To analyze the relationship between the effect of pingyangmycin on patients with oral squamous cell carcinoma and its related factors in the early stage of preoperative chemotherapy. Methods Forty three patients with oral squamous cell carcinoma who received preoperative chemotherapy with a total of 80 mg pingyangmycin were studied to analyze the relationship between the chemotherapeutic effect and the fever, duration of the fever, digestive system reaction and alteration of white blood cell counts with linear correlation, stepwise regression and student t test. Results Most of the responders (CR+PR, 17 cases) had local alterations within 3～6 days; the therapeutic effect of pingyangmycin was closely related to the fever, duration of the fever and digestive system reaction (P<0.05). Conclusion The effect of pingyangmycin on patients with oral squamous cell carcinoma can be predicted by the observation of the fever, duration of the fever, digestive system reaction and local alteration in the early stage.