摘要
目的分析补肾益智方联合针灸对阿尔兹海默症(AD)患者氧化应激指标水平的干预作用。方法选取我院2013年8月-2016年7月收治的86例AD患者,随机分为两组,均为43例。治疗组采取补肾益智方联合针灸治疗,对照组仅予针灸治疗。比较两组治疗前后简易精神量表(mini-mental state examination,MMSE)评分、日常生活能力量表(Activities of Daily Living,ADL)评分、AD行为病理评定量表(behavioral pathology in Alzheimer's disease,BEHAVE-AD)评分,并测定血清谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)、超氧化物歧化酶(Superoxide Dismutase,SOD)及丙二醛(malondialdehyde,MDA)水平变化。结果治疗后两组MMSE评分明显提高,ADL、BEHAVE-AD评分明显降低(P<0.01),但治疗组改善程度较对照组显著更优(P<0.01)。治疗后两组患者血清GSH-Px、SOD水平均明显上升,MDA水平明显下降(P<0.01),但治疗组改善幅度较对照组更明显(P<0.01);两组患者不良反应比较,差异无统计学意义(χ2=0.230,P=0.632)。结论补肾益智方联合针灸能提高AD患者机体抗氧化应激能力,显著改善认知功能、生活自理能力及精神行为症状,值得进一步深入研究。
Objective To analyze the intervention of the combined therapy of bushen yizhi formula and acupuncture on oxidative stress index in the patients of Alzheimer's disease( AD). Methods A total of86 AD patients were collected from August 2013 through to July 2016 and randomized into two groups,43 cases in each one. In the treatment group,the combined therapy of bushen yizhi formula and acupuncture was used. In the control group,acupuncture was used. The scores of MMSE( min-mental state examination),ADL( activities of daily living) and BEHAVE-AD( behavioral pathology in Alzheimer's disease) and the levels of GSH-Px( glutathione peroxidase),SOD( superoxide dismutase) and MDA( malondialdehyde) were compared before and after treatment in the two groups. Results After treatment,MMSE score was increased remarkably and the scores of ADL and BEHAVE-AD decreased remarkably in the two groups( P〈0. 01).The improvements in the treatment group were more significant than the control group( P〈0. 01). After treatment,the levels of serum GSH-Px and SOD were increased remarkably and MDA reduced in the two groups( P〈0. 01). The improvements in the treatment group was more apparent than the control group( P〈0. 01).The difference in the adverse reaction was not significant between the two groups( χ^2= 0. 230,P = 0. 632).Conclusion The combined therapy of bushen yizhi formula and acupuncture improves oxidative stress capacity,cognitive function and daily life activity as well as relieves mental behavior symptoms in the AD patients. A further study is required.
出处
《世界中西医结合杂志》
2017年第11期1554-1557,共4页
World Journal of Integrated Traditional and Western Medicine
关键词
补肾益智方
针灸
阿尔兹海默症
氧化应激
Bushen Yizhi Formula
Acupuncture
Alzheimer's Disease
Oxidative Stress