喜炎平联合干扰素治疗小儿轮状病毒肠炎的临床效果及对外周血中性粒细胞的影响

Clinical Effects on Infantile Rotavirus Enteritis and the Impacts on Peripheral Blood Neutrophils Treated with Xiyanping and Interferon

目的探讨喜炎平联合干扰素治疗小儿轮状病毒肠炎的临床效果及对患儿外周血中性粒细胞的影响。方法选择2014年10月-2015年10月我院接诊的80例轮状病毒肠炎的患儿,按照随机数字表法分为治疗组(40例)和对照组(40例),两组患者均进行综合性基础治疗,对照组使用干扰素雾化吸入,治疗组在对照组的基础上加用喜炎平注射液。观察两组患儿治疗前后中性粒细胞CD11b,记录在3 d、1周、2周、3周时大便轮状病毒的转阴率,对腹痛、腹泻、恶心呕吐、腹鸣、发热各体征的缓解时间及治疗后临床疗效进行记录。结果治疗后,治疗组中性粒细胞CD11b(81.14±3.15)%低于对照组(87.62±3.26)%;在1周、2周、3周时,治疗组轮状病毒转阴率[67.50%(27/40),90.00%(36/40),100%(40/40)]均高于对照组[37.50%(15/40),72.50%(29/40),90.00%(36/40)](P<0.05);治疗组腹痛、腹泻、恶心呕吐、腹鸣缓解时间[(2.48±0.31)d,2.76±0.29)d,(1.51±0.24)d,(4.11±0.53)d,(1.62±0.50)h]均短于对照组[(3.45±0.42)d,(3.65±0.37)d,(2.33±0.32)d,(6.46±0.81)d,(2.78±0.72)h](P<0.05);治疗组治疗后总有效率92.50%(37/40)高于对照组72.50%(29/40),差异有统计学意义(P<0.05)。结论喜炎平联合干扰素治疗小儿轮状病毒肠炎疗效显著,能有效降低中性粒细胞CD11b的表达水平,快速改善消化道症状,值得临床应用推广。

Objective To explore the clinical effects on infantile rotavirus enteritis and the impacts on peripheral blood neutrophils treated with xiyanping and interferon. Methods From October 2014 through to October 2015,80 cases of infantile rotavirus enteritis were treated in the hospital. According to the random number table,they were divided into a treatment group（ 40 cases） and a control group（ 40 cases）. The comprehensive regimen was adopted in the two groups. Additionally,in the control group,interferon aerosol inhalation was used. In the treatment group,on the base of the treatment as the control group,xiyanping injection was added. The neutrophile CD11 b were observed before and after treatment in the two groups. On day 3 and in week 1 and 2,the negative conversion rate was recorded. The remission time of abdominal pain,diarrhea,nausea,vomiting,bowel sound and fever,as well as the clinical therapeutic effects were recorded. Results After treatment,the granulocyte CD11 b[（ 81. 14 ± 3. 15） %]in the treatment group was lower than[（ 87. 62 ±3. 26） %]in the control group. In week 1,2 and 3,the negative conversion rate of rotavirus in the treatment group[67. 50%（ 27/40）,90. 00%（ 36/40）,100%（ 40/40） ]was higher than[37. 50%（ 15/40）,72. 50%（ 29/40）,90. 00%（ 36/40） ]in the control group. The remission time of abdominal pain,diarrhea,nausea,vomiting and bowel sound was[（ 2. 48 ± 0. 31） d,（ 2. 76 ± 0. 29） d,（ 1. 51 ± 0. 24） d,（ 4. 11 ± 0. 53） d,（ 1. 62 ± 0. 50）h]shorter than[（ 3. 45 ± 0. 42） d,（ 3. 65 ± 0. 37） d,（ 2. 33 ± 0. 32） d,（ 6. 46 ± 0. 81） d,（ 2. 78 ± 0. 72） h]in the control group separately（ P〈0. 05）. The total therapeutic effective rate was 92. 50%（ 37/40） in the treatment group,higher than 72. 50%（ 29/40） in the control group after treatment,indicating the significant difference（ P〈0. 05）. Conclusion The combined treatment of xiyanping and interferon achieves the significant therapeutic effects on infantile rotavirus enteritis. It effectively reduces the expression of neutrophil CD11 b and relieves rapidly the digestive symptoms. Hence,this therapy deserves to be promoted in clinical application.