表观健康人群血糖、血脂和血清蛋白含量随年龄变化的趋势

Changes of serum glucose,lipid and protein with age in apparently healthy populations

目的观察表观健康人群血糖、血脂和血清蛋白含量随年龄变化的趋势,为参考范围的建立和疾病预防提供科学依据。方法募集表观健康体检志愿者4041名,收集年龄和性别信息,使用全自动生化分析仪检测血糖(GLU)、血脂(TC、HDLc、LDLc、TG)、血清总蛋白(TP)和白蛋白(ALB),分析这些指标随年龄的变化趋势。结果血糖、血脂和血清蛋白随年龄呈递增或递减的单向变化趋势(P<0.01)。GLU(5.05±0.43)mmol/L、TC(4.39±0.6)mmol/L、LDLc(2.39±0.51)mmol/L和TG(0.79±0.34)mmol/L血清含量随年龄递增,HDLc(1.52±0.3)mmol/L、TP(74.03±3.81)g/L和ALB(47.79±2.86)g/L随年龄递减,Cox-Stuart.趋势检验发现这种随年龄单调变化趋势具有统计学意义(P<0.01)。结论血糖、血脂和血清蛋白在表观健康人群中具有增龄现象,提示临床建立参考范围时应考虑年龄因素的影响。对糖尿病、冠心病和其他老年性慢性疾病应监测血糖、血脂和血清蛋白的改变,以便进行早防早诊早治。

Objective To observe the patterns of change of serum glucose, lipid and protein with age in apparently healthy populations in order to contribute to the determination of the reference range and disease prevention. Methods A total of 4041 appar- ently healthy volunteers were recruited along with information on their age and gender. Serum levels of glucose, lipid （TC, HDLc, LD- Lc, TG） and protein （TP, ALB） were detected with an automatic biochemical analyzer. The relationships between these indexes and age were explored. Results Serum glucose, lipid and protein levels increased or decreased gradually with age （ P 〈 0.01 ）. Among these indexes, serum levels of GLU （5.05 ± 0.43 ） mmol/L, TC （4.39 ± 0.6） mmol/L, LDLc （2.39± 0.51 ） mmol/L and TG （0.79±0.34） mmol/L increased, but HDLe （ 1.52± 0.3 ） mmol/L, TP （74.03 ± 3.81 ） g/L and ALB （47.79 ± 2.86） g/L decreased with age, respectively. Trend analysis with the Cox-Stuart test in R showed that the monotonic trend of change with age was very significant （ P 〈 0.01 ）. Conclusions Serum levels of glucose, lipid and protein vary with age, suggesting that the influence of age has to be taken into consideration in the process of establishing the clinical reference range. For patients of diabetes, coronary heart diseases and other senile chronic diseases, these tests should be conducted regularly to prevent, diagnose and treat diseases as soon as possible.