中药白花前胡防治心律失常作用的实验研究Ⅱ——对大鼠冠脉结扎诱发心律失常的影响

EXPERIMENTAL EFFECTS OF BAI HUA QIAN HU, A CHINESE TRADITIONAL HERB. ON THE PREVENTION AND THERAPY OF ARR HYTHMIA Ⅱ: EFFECIS ON THE RAT ARRHYTHMIA INDUCED BY THE LIGATION OF THE LEFT CORONARY ARTERY

预先静注白花前胡水醇提取液(1 g/kg),再结扎大鼠左冠状动脉,可大大减少室性心律失常的发作程度和持续时间。总发作率由对照组的100%降至70%(P<0.01)。结扎后对照组均发生程度渐重的T波高耸、ST段上移等ECG异常,死亡率较高。而实验组却少见上述现象。

The degree and duration of the rat ventricular arrhythmia induced by theacute ligation of the left coronary artery were markedly decreased within 30min after the pretreatment with Bai Hua Qian Hu (1g/kg, iv). The totalincidence was lowered from 100% (control) to 70% (P<0.01). ECG abnormalchanges was lightened and a low mortality was observed in the tested groupafter the occlusion of the coronary artery.