华法林药代动力学过程影响因素研究进展

Research progress on pharmacokinetics factors of warfarin

华法林作为临床上应用最广泛的口服抗凝药,因其较窄的治疗窗,绝大部分关于华法林的文献资料均聚焦于其安全性和临床剂量的设计。目前各种华法林临床剂量调整的预测公式往往只能解释华法林40%~60%的剂量个体化差异。本文对华法林体内药代动力学过程的诸多影响因素及可能的药物相互作用进行了文献分析,以期为促进华法林的临床合理应用提供药代动力学方面的依据。

Warfarin is the most frequently used oral anticoagulants,but most literatures of it focused on the safety and clinical dosages design due to its narrow therapeutic window.The various prediction formulae of clinical dose-adjustment of warfarin can only interpreter 40%-60% individualized difference of warfarin.This article reviews literatures about the factors influencing pharmacokinetics of warfarin and its potential drug interactions so as to provide referential evidences for the rational application of warfarin into clinic.