骨髓增生异常综合征患者染色体异常与细胞形态学的相关性分析

Correlation between Chromosomal Abnormality and Cell Morphology with Myelodysplastic Syndrome Patients

目的总结分析骨髓增生异常综合征患者(MDS)细胞形态学异常与染色体异常的相关性。方法回顾性分析82例MDS患者完整的病例资料,探讨MDS细胞形态学异常与FISH检测染色体异常的相关性。结果 82例MDS患者中,染色体异常45例,+8为出现频率最高的染色体异常,其中单纯+8异常8例,-5和5q-各6例、20q-7例、-7和7q-各5例、复杂核型(>3种异常)6例、+8伴20q-1例,5q-伴20q-1例。核型异常组与核型正常组之间原始细胞比例、幼红细胞巨幼样变及核畸形、巨核细胞系发育异常(单圆核巨核细胞、多圆核巨核细胞、小巨核细胞)比例差异有统计学意义(P<0.05)。高危组与低危组间、低危组与中危组间核型异常比例差异有统计学意义(P<0.05)。结论 MDS患者的染色体异常与形态学改变可能相关。

Objective To investigate the correlation between morphological abnormalities and abnormal myelodysplastic syn-dromes（MDS）cloning.Methods 82 cases of MDS were collected with complete FISH and morphological abnormalities. The relationship between MDS cell morphology and chromosome abnormality was investigated.Results 45 cases of chromo-somal abnormalities were found,and ＋8 were the most frequent chromosomal abnormalities.8 cases were ＋8,-5 and 5q-were 6,20q-were 7,-7 and 7q-were 5,complex karyotypes（〉3 abnormalities）were 6.There were statistically significant differences in the proportion of primordial cells,megakaryocyte dysplasia,megakaryocyte abnormalities between karyotype abnormal group and karyotype normal group（P〈0.05）.There were statistically significant differences in the proportion of abnormal karyotype among high risk group and low risk group,the low risk group and medium risk group（P〈0.05）.Con-clusion The chromosomal abnormalities of MDS patients would be related to morphological changes.