低氧诱导因子2在肿瘤发生发展中的作用和机制

The role and mechanisms of hypoxia inducible factor(HIF)-2 in cancer development

低氧是肿瘤发生和发展中的一种常见的微环境。低氧诱导因子1和低氧诱导因子2介导了肿瘤细胞对低氧环境的适应性应答,尽管两者具有高度的同源性,但各自具有独特的功能。近来对低氧诱导因子2的研究表明,它在肿瘤的代谢、增殖、血管生成、转移、化疗耐药等方面有着非常重要的作用。现从以上方面对低氧诱导因子2在肿瘤发生发展中的作用和机制进行综述。

Hypoxia is a common environment in cancer development. Hypoxia inducible factor-1 （HIF-1） and HIF- 2 mediate the cellular adaptive response to hypoxia. Despite the high homology between HIF-1αand HIF-2α, they have particular functions respectively. Recent studies metabolism, proliferation, angiogenesis, metastasis and mechanisms of HIF-2 in cancer development. have shown that HIF-2 plays a critical role in cancer drug resistances. We summarize the role and molecular