CT强化幅度与食管癌病理形态学和血管内皮生长因子表达间的关系

The Relationship of CT Enhancement Magnitude between the Pathological Morphology and the Expression of VEGF in Esophageal Carcinoma

目的:对56例食管癌患者血管内皮生长因子(VEGF)表达结果与CT强化峰值参数间进行对照,研究其相关性,为食管癌的影像学诊断及早期发现提供参考依据。方法:56例患者均于术前行CT平扫+动态增强扫描,记录不同扫描时期病灶的CT平扫值、增强峰值;VEGF在正常食管粘膜和食管癌组织中的表达用免疫组织化学法(SP法)测定。所有数据均通过SPSS 21.0统计软件处理。结果:VEGF的表达增强可能是鳞状细胞癌恶性度增高及发生淋巴结转移的标志,CT扫描增强幅度与食管癌中VEGF表达强弱无关。结论:VEGF的表达增强可能是鳞状细胞癌的发生及淋巴结发生转移的标志,CT扫描中病灶增强幅度不能反应肿瘤淋巴结的转移。

Objective： To compare the expression of VEGF and the peak value of CT in 56 patients with esophageal cancer, and to study the correlation between them, and to provide reference for imaging diagnosis and early detection of esophageal cancer. Methods： Before operation, fifty-six cases of patients had an examination by routine and dynamic enhanced CT scan, get the CT scan value and enhance the peak value of each phase lesion. The positive expression of VEGF in esophageal mucosa and esophageal cancer tissues of control group was determined by immunohistochemical technique. Used statistical software SPSS 21.0 to process statistical analysis of all experimental data. Results： Enhancement of VEGF expression is related possibly to occurrence and metastasis of squamous cell carcinoma by lymph-vessel. These results showed that CT enrichment degree was not related to VGEF expression in esophageal mucosa of squamous cell carcinoma, indicating that CT enrichment degree in lesion do not respond directly lymph node metastases of carcinoma. Conclusion： Enhanced expression of VEGF may be a marker of squamous cell carcinoma and lymph node metastasi, The enhancement of the lesion in the CT scan could not reflect the metastasis of the tumor lymph nodes.