心外膜及心周脂肪体积与颈动脉粥样斑块的关系

Correlation of Epicardial Adipose Tissue and Pericardial Adipose Tissue with Carotid Artery Plaque

目的:探讨CT平扫测量心外膜及心周脂肪体积与颈动脉粥样硬化斑块的关系。方法:选取开滦集团高管健康查体职工475例,均接受胸部CT平扫检查,测量相应心外膜及心周脂肪体积。根据颈动脉彩超结果将其分为有斑块组165例和无斑块组310例,并进一步以BMI(kg/m2)"24"、"28"分别作为超重、肥胖的界限,将其分为正常体重组129例、超重组258例和肥胖组88例。分别研究正常体重组、超重组和肥胖组中有无颈动脉斑块者的心外膜及心周脂肪体积的相关性。结果:正常体重组有颈动脉斑块者45例,无斑块者84例;超重组有斑块者86例,无斑块者172例;肥胖组有颈动脉斑块者34例,无斑块者54例,3组中有颈动脉斑块的心外膜及心周脂肪体积均大于无颈动脉斑块的,差异有统计学意义(P<0.05)。结论:心外膜及心周脂肪体积随着肥胖程度的增加而增加,排除BMI因素,心外膜及心周脂肪体积与颈动脉粥样硬化斑块形成具有较强的相关性。

Objective： To explore the relationship among epicardial adipose tissue （EAT）, pericardial adipose tissue （PAT） and carotid artery plaque. Methods： The routine health check-up data of 475 senior managers in Kailuan Corporation were collected and analyzed. All of them underwent chest CT scan examination, EAT and PAT volume were measured, according to the carotid ultrasound, the health check-up data was divided into plaque group （165 cases） and non-plaque group （310 cases）, based on BMI, taking BMI 〈 24 as normal weight group, 24 〈 BMI 〈 28 as overweight group, BMI 〉 28 as obesity group, moreover, the correlation of EAT and PAT volume in normal weight group, overweight and obesity group with or without carotid plaque was studied respectively. Results： There were 45 cases with carotid plaques and 84 cases without plaques in normal weight group, 86 subjects with carotid plaques and 172 subjects without carotid plaques in overweight group, obesity group included 34 cases with carotid plaques and 54 cases without carotid plaques, the EAT and PAT volume of the subjects with carotid plaques in three groups were higher than those without carotid plaques （P 〈 0.05）. Conclusion： EAT and PAT increase with obesity. After adjusting BMI, the EAT and PAT volume have a strong correlation with the formation of carotid plaques.