中西医联合治疗对神经性耳鸣患者症状体征评分及血液5-HT水平的影响

Effect of symptoms and signs and blood 5-HT expression after aeurotic tinnitus patients treated with combination of TCM and western therapies

目的:探讨中西医联合治疗对神经性耳鸣患者症状体征评分及血液5-羟色胺(5-HT)水平的影响。方法:选取2015年6月至2016年12月进行治疗的160例神经性耳鸣患者,将患者按照随机数字表法分为对照组和观察组,各80例。对照组使用右旋糖酐进行注射治疗,观察组在对照组的治疗基础上使用中医捻转针刺法治疗。分别对两组患者治疗前后的临床症状评分以及5-HT水平进行比较,同时比较两组患者的治疗有效率和不良反应发生率。结果:治疗前两组患者临床症状评分差异无统计学意义(P>0.05);治疗后观察组6项评分均显著低于对照组(P<0.05),观察组的治疗有效率显著高于对照组(P<0.05)。两组治疗前5-HT水平比较差异无统计学意义(P>0.05);治疗后两组血清5-HT水平显著下降(P<0.05),且观察组显著低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:中西医联合治疗神经性耳鸣具有更好的临床疗效,可能与其调节5-HT水平有关,并且此种方法具有一定安全性。

Objective：To investigate the effect of combination of traditional Chinese medicine and western medicine on symptom score and blood serotonin expression in patients with neurological tinnitus.Methods：A total of 160 patients with neurological tinnitus who were treated from June 2015 to December 2016 were enrolled in this study.The patients were divided into control group and observation group according to the randomized number table.80 patients in the control group were treated with Dextran,80 patients in the observation group were treated with Chinese acupuncture based on the treatment of the control group.The clinical symptom scores and 5-HT levels were compared between the two groups before and after treatment,and the incidence of treatment and the incidence of adverse reactions were compared between the two groups.Results：There were no significant differences in clinical symptoms between the two groups before treatment（P〉0.05）.And the six scores of the observation group were significantly lower than those of the control group（P〈0.05）.There was a significant difference between the two groups（P〈0.05）.The effective rate in the observation group was significantly higher than that in the control group（P〈0.05）.There was no significant difference in the levels of 5-HT between the two groups before treatment（P〉0.05）.After treatment,serum 5-HT levels were significantly decreased in both groups（P〈0.05）.5-HT levels of the observation group was significantly lower than that of the control group（P〈0.05）.There was no significant difference in the incidence of adverse events between the two groups（P〉0.05）.Conclusion：Traditional Chinese medicine and western medicine treatment of neurological tinnitus has a better clinical efficacy,which is possiby related to its regulation of 5-HT levels,and has a certain safety.