分析三苯氧胺对浆细胞乳腺炎急性发病初期治疗效果的影响

Effect of Tamoxifen on the Acute Onset of Plasma Cell Mastitis

目的分析三苯氧胺对浆细胞乳腺炎急性发病初期治疗效果的影响。方法选取我院2015年3月~2017年4月收治的110例浆细胞乳腺炎患者为研究对象,按照随机分配原则分为实验组和对照组,各55例。对照组患者给予泼尼松治疗,实验组患者给予三苯氧胺治疗,对比分析两组患者临床治疗效果。结果实验组患者治疗后乳房疼痛评分为(2.13±0.05)分,乳房肿块直径评分为(3.04±0.41)分,肿块皮肤评分为(3.06±0.46)分,实验组患者以上三项指标下降程度显著优于对照组(P<0.05);实验组患者中治疗前Ki67表达>30%有39例,占比为70.91%,治疗一个月后有7例,占比为12.73%,明显优于对照组(P<0.05)。结论三苯氧胺在浆细胞乳腺炎急性发病初期治疗上有很好的临床治疗效果,值得在临床上推广应用。

Objective To investigate the effect of tamoxifen on the acute onset of plasma cell mastitis. Methods A total of 110 patients with plasma cell mastitis were randomized into the experimental group and control group from March 2015 to April 2017, 55 cases in each group. The control group was treated with prednisone. The experimental group received tamox-ifen. The clinical effect was compared between the two groups. Results After treatment, the scores of breast pain, breast mass,and lump skin in the experimental group were better than those in the control group （（2. 13 ± 0. 05） vs （4. 38±1. 03） 〉 （3. 04±0. 41） vs （4.53± 1. 09）,（ 3. 06±0. 46） vs （4. 51 ± 1. 0 8 ） ,all P〈0. 05）. Before treatment,there were 39 cases of Ki67 〉30% in the experimental group,accounting for 70. 91%. After 1-month treatment,there were 7 cases of Ki67 〉30% in the experimental group, accounting for 12. 73%, which was better than the control group （30（54. 55%）） （P〈0 . 05）. Conclusion Tamoxifen has a great effect in the treatment of plasma cell mastitis at acute onset, worthy of clinical application.