氯噻嗪联合氨氯地平对老年原发性高血压患者血压及肾功能的影响

Influence of Hydrochlorothiazide Combined with Amlodipine on Blood Pressure and Renal Function in Eelderly Patients with Primary Hypertension

目的探讨氢氯噻嗪联合氨氯地平对老年原发性高血压患者血压及肾功能的影响。方法将收治的90例患者随机分为对照组(45例)与观察组(45例),对照组接受氨氯地平治疗,观察组接受氢氯噻嗪联合氨氯地平治疗,现对比分析两组患者的舒张压、收缩压、24h尿微量白蛋白、尿微量白蛋白/尿肌酐比值、估算肾小球滤过率等指标。结果治疗前,两组患者舒张压、收缩压,24h尿微量白蛋白、尿微量白蛋白/尿肌酐比值、估算肾小球滤过率比较差异无统计学意义(P>0.05)。治疗8周后,观察组舒张压、收缩压、24h尿微量白蛋白、尿微量白蛋白/尿肌酐比值显著低于对照组(P<0.05);估算肾小球滤过率显著高于对照组(P<0.05)。结论氢氯噻嗪联合氨氯地平治疗老年原发性高血压患者的疗效确切,可以获得较好的降压效果以及肾功能改善。

Objective To investigate the influence of hydrochlorothiazide combined with amlodipine on blood pressure and renal function in elderly patients with primary hypertension. Methods 90 cases were divided intocontrol group（45 cases） and observation group（45 cases） randomly, and control group was given hydrochlorothiazide, while observation group re-ceived hydrochlorothiazide combined with amlodipine, then the diastolic blood pressure（DBP） , systolic blood pressure（SBP）, 24h urinary albumin（4h-UmAlb） ？ urinary albumin/urine creatinine ratio（UmAlb/UCr） , estimated glomerular filtration rate （eGFR） between the 2 groups were compared. Results Before treatment, there were no obvious differences in DBP,SBP,24h- UmAlb,UmAlb/UCr,Egfr between the 2 groups（P〉0. 05）. After 8 weeks of treatment, DBP？SBP,24h-UmAlb,UmAlb/ UCrof observation group were obviously lower than those of control group（P〈C0. 05） while eGFR was obviously higher than control group（P〈0 . 05）. Conclusion The hydrochlorothiazide combined with amlodipine in the treatment of elderly patients with primary hypertension shows good efficacy 〉 which has better antihypertensive effect and renal function improvement.