脑微出血患者血清Aβ1-40、Aβ1-42的检测及其意义

Serumlevel Detection and Clinical Significance of Aβ1-40 and Aβ1-42 in Patients with Cerebral Hemorrhage

目的对脑微出血患者血清Aβ1-40和Aβ1-42的检测进行分析,探讨检测的临床意义。方法选择2015年6月~2016年6月在本院进行治疗的急性腔隙性脑梗死患者50例作为观察组,并选择同期在我院进行治疗的未出现急性腔隙性脑梗死的患者50例作为对照组,检测并比较两组患者的血清Aβ1-40和血清Aβ1-42变化情况。结果对照组患者血清Aβ1-40浓度为(46.24±12.46)pg/mL,血清Aβ1-42浓度为(57.41±15.10)pg/mL,观察组患者血清Aβ1-40浓度为(53.98±13.54)pg/mL,血清Aβ1-42浓度为(47.19±8.92)pg/mL,观察组的血清Aβ1-40浓度高于对照组,血清Aβ1-42浓度低于对照组,两组相比差异均具有显著性(均P<0.05)。结论血清Aβ1-40个血清Aβ1-42水平的变化与脑微出血具有相关性,可作为脑微出血的一个诊断指标,反应病变程度,为疾病的诊断和治疗提供依据。

Objective To analyze the s e rum level detection of Aβ1-40 and Aβ1-42 in patients with cerebral hemorrhage, and to explore the clinical significance of the detection. Methods 50 patients with acute lacunar cerebral infarction w h o were treated in our hospital from June 2015 to June 2016 were selected as observation group, and another 50 patients without acute lacunar infarction who were also treated in our hospital in the same period were recruited in the control group. The serum lev-els of Aβ1-40 and Aβ1-42 were detected and compared between the two groups. Results T h e s e r u m Aβ1-40 concentration in the control group was （46. 24 ± 12. 46） pg/ml and the serum Aβ1-42 concentration was （57. 41± 15. 10） pg/ml. The serum Aβ1-40 concentration was （53. 98± 13. 54） p g / m l in the control group and the concentration of s erum Aβ1-42 w a s （47. 1 9± 8. 92） pg/ml, the concentration of Aβ1-40 in the observation group was higher than that in the control group, and the concen-tration of Aβ1-42 in the observation group was lower than that in the control group（P〈0. 05）. Conclusion Changes of s erum Aβ1-40 and Aβ1-42 level are associated with cerebral microbleeds 〉 which can act as a diagnostic index of cerebral microbleeds and reflect the degree of the disease. With the high clinical value it also provides the basis for the diagnosis and treatment of disease.