CA125、CA199及CEA联合检测在卵巢癌诊断中的应用价值

The Value of Combined Detection of CA125,CA199 and CEA in the Diagnosis of Ovarian Cancer

目的探讨血清肿瘤标记物糖类抗原CA125、糖类抗原CA199及癌胚抗原CEA联合应用在卵巢癌诊断中的应用价值。方法收集80例卵巢癌患者为研究组,同时期80例卵巢良性肿瘤患者为对照组,80例健康体检患者为健康组,利用化学发光法比较三种标记物联合应用与单项检测的差异。结果研究组患者的肿瘤标记物CA125、CA199及CEA水平均明显高于良性肿瘤组及健康组;良性肿瘤组CA125水平显著高于健康组,CA199及CEA水平无显著差异;联合应用检测卵巢癌的阳性率的阳性率及灵敏度均较单项检测有明显提高。结论对三种肿瘤标记物进行联合检测可及早准确地对卵巢癌进行诊断。

Obje c tive To investigate the value of combined use of serum tumor markers, carbohydrate antigen CA125, carbohydrate anigen CA199 and carcinoembryonic antigen CEA in diagnosis of ovarian cancer. Methods 80 cases of ovarian cancer patients were selected in the study group？ and 80 cases of benign ovarian tumor patients were as the control group〉 and 80 healthy patients were as healthy group, and luminescence method The individual difference of the three markers were com-pared with combined detection. Results The level of CA125 ？ CA199 and CEA levels were significantly higher than those in be-nign tumor group and healthy group. The level of CA125 in benign tumor group was significantly higher than that in healthy group, and there was no significant difference between the CA199 and CEA level. The positive rate of combined detection of ovarian cancer and sensitivity than single detection is obviously improved. Conclusion The combined detection of three tumor markers can diagnose ovarian cancer accurately and early.