胃肠安丸联合多潘立酮治疗儿童功能性消化不良的效果观察

Effect of Weichang′an Pill combined with domperidone on functional dyspepsia in children

目的观察胃肠安丸联合多潘立酮治疗儿童功能性消化不良(functional dyspepsia,FD)的效果及对血清P物质、胃动素(motilin,MOT)、一氧化氮(nitric oxide,NO)和5-羟色胺(5-hydroxytryptamine,5-HT)的影响。方法将110例FD患儿按照随机数字表法分为2组各55例,对照组给予口服多潘立酮片治疗,观察组在对照组基础上给予胃肠安丸治疗,2组疗程均为4周。观察2组治疗前后临床主要症状、胃电图以及血清P物质、5-HT、MOT和NO水平的变化,并比较2组治疗的临床效果。结果 2组治疗后上腹痛、餐后饱胀、厌食、早饱、反酸、恶心呕吐等症状积分和总积分均较治疗前显著降低(P<0.05),治疗后观察组以上临床症状评分均低于对照组(P<0.05);2组治疗后(餐前、餐后)胃电图中的胃动过缓及胃电节律异常率显著下降(P<0.05),观察组治疗后异常率低于对照组(P<0.05);观察组治疗总有效率优于对照组(P<0.05);2组治疗后血清P物质、5-HT、MOT和NO水平均较治疗前显著升高(P<0.05),治疗后观察组上述指标均高于对照组(P<0.05)。结论在多潘立酮基础上加用胃肠安丸治疗能够显著改善FD患儿的临床症状,增强胃动力,提高临床治疗效果,其机制可能与上调血清P物质、5-HT、MOT和NO含量有关。

Objective To observe the effect of Weichang′an Pill on functional dyspepsia(FD)in children and its influence on serum substance P,5-hydroxytryptamine(5-HT),motilin(MOT)and nitric oxide(NO).Methods One hundred and ten cases of children with FD were divided into two groups according to random number table,each group with 55 cases.Control group was given Domperidone Tablets,observation group was given Weichang′an Pill on the basis of control group,and course of treatment was 4 weeks.Clinical symptoms,electrogastrogram and serum substance P,5-HT,MOT and NO were observed in two groups before and after treatment.The clinical efficacy of two groups was compared.Results The scores of abdominal pain,after eating full bilge,anorexia,early enough,anti acid nausea and vomiting and total score were decreased significantly after treatment between two groups(P<0.05).The clinical symptoms were lower than the control group after treatment(P<0.05).In the 2 groups after treatment(before meal and after meal),the gastric motility and the abnormal rate of gastric electrical rhythm were significantly decreased(P<0.05).After treatment,the abnormal rate of observation group was lower than that of control group(P<0.05).The total effective rate of observation group was better than that of control group(P<0.05).The levels of serum substance P,5-HT,MOT and NO in the 2 groups were significantly higher than those before treatment(P<0.05).The above indexes in the observation group were higher than those in the control group(P<0.05).Conclusion In the basis of domperidone in the treatment of children with FD,the treatment of Weichang′an Pill can significantly improve the clinical symptoms of children with FD,enhance the gastric motility,and improve the clinical efficacy.The mechanism may be related to the up regulation of serum substance P,5-HT,MOT and NO levels.