左氧氟沙星联合哌拉西林/他唑巴坦在重症社区获得性肺炎中的疗效评价

Efficacy of Levofloxacin Combined with Piperacillin/Tazobactam in Severe Community-acquired Pneumonia

目的:探讨左氧氟沙星联合哌拉西林/他唑巴坦在治疗重症社区获得性肺炎中疗效以及安全性。方法:选取2014.07—2017.08我院收治的96例重症社区获得性肺炎患者为研究对象,给予左氧氟沙星联合哌拉西林/他唑巴坦静脉滴注进行治疗,治疗疗程为7~14d,平均(11.5±2.3)d,回顾性分析其临床显效时间、细菌清除率、平均有效率、不良反应等。结果:细菌清除率达84.34%;白细胞恢复正常时间为(6.02±0.46)d、体温恢复正常时间为(3.98±0.83)d、痰液恢复正常时间为(13.76±1.12)d;临床有效率为88.54%;患者出现的不良反应主要包括:肝功能异常、兴奋、皮疹、胃肠道反应以及白细胞减少,经对症处理或停药后均消失,其不良反应发生率仅为7.29%。结论:左氧氟沙星联合哌拉西林/他唑巴坦在治疗重症社区获得性肺炎中疗效显著,不良反应发生率低,安全性高,值得临床推广应用。

Objective To investigate the efficacy and safety of levofloxacin combined with piperacillin / tazobactam in the treatment of severecommunity-acquired pneumonia. Methods： Ninty-six patients with severe community-acquired pneumonia from 2014.07 to 2017.08 were enrolled inthis study. The patients were treated with levofloxacin combined with piperacillin / tazobactam intravenous infusion for 7 to 14 days with an averageof （11.5±2.3） d, retrospective analysis of its clinical markedly time, bacterial clearance rate, the average efficiency, adverse reactions. Results： Thebacterial clearance rate was 84.34%; the normal time of white blood cell recovery was （6.02±0.46） d, the normal time of body temperature returnedwas （3.98±0.83） d, the normal time of recovery of sputum was （13.76±1.12） d; clinical response rate was 88.54%; adverse reactions in patientsmainly include： abnormal liver function, excitement, rash, gastrointestinal reactions and leucopenia. After symptomatic treatment or withdrawal wasdisappeared, the incidence of adverse reactions was only 7.29%. Conclusion： Levofloxacin combined with piperacillin / tazobactam has a significanteffect in the treatment of severe community acquired pneumonia. The incidence of adverse reactions is low and the safety is high, which is worthy ofclinical application.