血小板/淋巴细胞比值与急性一氧化碳中毒患者心肌损伤的关系

Relationship between platelet-to-lymphocyte ratio and myocardial injury in patients with acute carbon monoxide poisoning

目的探讨血小板/淋巴细胞比值(PLR)与急性一氧化碳中毒(ACOP)患者心肌损伤的关系。方法回顾性分析211例ACOP患者的临床资料,根据肌钙蛋白I水平分为无心肌损伤组128例和心肌损伤组83例,比较两组的一般临床资料、PLR值及心肌酶等,采用logistic回归分析ACOP患者心肌损伤的危险因素;采用受试者工作特征(ROC)曲线评价入院时PLR对ACOP患者心肌损伤的预测作用。结果 PLR及WBC计数升高、男性为ACOP患者心肌损伤的独立危险因素(P<0.05)。入院时PLR对ACOP患者心肌损伤的诊断界值为4.70时,其敏感度为88.0%,特异度为43.0%,曲线下面积为0.747。结论入院时PLR增高时ACOP患者出现心肌损伤的风险增高,其对患者心肌损伤具有一定的预测价值。

Objective To investigate the relationship between platelet-to-lymphocyte ratio（ PLR） and myocardial injury in patients with acute carbon monoxide poisoning（ ACOP）. Methods The clinical data of 211 patients with ACOP were retrospectively analyzed. All subjects were divided into non-myocardial injury group（ n = 128） and myocardial injury group（ n = 83） according to their troponin-I levels.The general clinical data,PLR and cardiac enzymes were compared between the two groups. Logistic regression analysis was used to analyze the risk factors for myocardial injury in patients with ACOP. The receiver operating characteristic（ ROC） curve was used to evaluate the predictive efficiency of PLR on admission for myocardial injury in patients with ACOP. Results Elevated PLR and WBC counts,and male were the risk factors for myocardial injury in patients with ACOP（ P 0. 05）. The sensitivity,specificity and the area under curve were88. 0%,43. 0% and 0. 747 respectively when the diagnostic cut-off value of PLR on admission for myocardial injury in patients with ACOP was 4. 70. Conclusion The patients with ACOP might be at a higher risk of myocardial injury when PLR on admission increases,and this index is valuable for predicting myocardium injury to a certain.