基于聚类分析黄文东后人龚雨萍主任治疗慢性非特异性溃疡性结肠炎的用药规律研究

Study the medication rules of Director Gong Yuping on chronic nonspecific ulcerative colitis based on cluster analysis

目的探讨和总结黄文东后人龚雨萍主任治疗慢性非特异性溃疡性结肠炎(CUC)的学术思想和临床用药规律。方法收集龚主任治疗CUC医案299例,对所选医案中符合纳入标准的药物运用Excel表进行收录,然后用SPSS 22.0统计软件进行聚类分析。结果 (1)共有299例医案纳入研究,共计就诊457次;共得药物224味,出现的总频次为7 420,常用中药有白术、茯苓、马齿苋、生地榆等36味。(2)聚类分析发现益气健脾、健脾温肾、健脾利湿、活血化瘀、凉血止痢药为龚主任治疗CUC的常用配伍药类。(3)四君子汤、参苓白术散、香砂六君子汤、白头翁汤等为龚主任治疗CUC的基本方药。结论龚主任治疗CUC体现出以脾胃为根本,注重辨证论治、寒热并用、标本兼顾的学术思想,聚类分析结果客观反映了龚主任临床用药规律。

Objective To discuss and summarize the academic thinking and clinical medication rules of the posterity of Hang Wendong--Director Gong Yuping on chronic nonspecific ulcerative colitis( CUC). Methods299 typical cases of CUC treated by Director Gong were collected,which meeting the inclusion criteria were recorded by using Excel table,and by using SPSS 22. 0 statistical software for cluster analysis. Results(1)A total of 299 medical cases were included in the study,a total of 457 visits,involved 224 herbs,and total appearance frequency was 7 420. And 36 kinds of herbs were commonly used,such as atractylodes,poria cocos,purslane,Rradix rehmanniae elm,and so on.(2)Cluster analysis found that the herbs were mainly used by Director Gong on CUC were tonifying Qi and spleen,strengthen spleen and warm kidney,invigorating spleen to remove dampness,promoting blood circulation to remove blood stasis and cooling blood to stop diarrhea.(3)The basic decoction of Director Gong on CUC were Sijunzi decoction,Shenling-baizhu powder,Xiangsha-liujunzi decoction and Baitouweng decoction.Conclusion Taking the spleen and stomach as the foundation,emphasizing syndrome differentiation and treatment,cold combined with heat and simultaneous treatment method of superficiality and origin. The results of cluster analysis objectively reflect the medication rules of Director Gong on CUC.