摘要
目的:考查血必净注射液分别与注射用七叶皂苷钠和注射用血塞通的配伍稳定性。方法:观测血必净注射液分别与注射用七叶皂苷钠和注射用血塞通(以10%葡萄糖溶液为溶媒)配伍后,室温放置8 h内的可见异物、pH值、不溶性微粒、渗透压及羟基红花黄色素A、芍药苷含量(采用高效液相色谱法测定)的变化。结果:血必净注射液分别与注射用七叶皂苷钠和注射用血塞通配伍后8 h内可见异物、pH值、不溶性微粒、渗透压及羟基红花黄色素A和芍药苷含量均无明显变化。结论:血必净注射液与注射用七叶皂苷钠或注射用血塞通配伍8 h内稳定。
Objective : this paper respectively studied the compatible stability of Xuebijing injection with sodium aescinate and Xuesaitong for injection. Methods : After mixing Xuebijing injection with sodium aescinate for injection and Xuesaitong for injection(with 10% glucose solution as a solvent), respectively, visible particles, pH values, insoluble particles, osmotic pressure changes were observed at room temperature within 8 hours, and the content of hydroxy safflower yellow pigment A and paeoniflorin change were determined by high performance liquid phase chromatography. Results : No obvious changes were found in visible particles,pH value, insoluble particles, osmotic pressure and the content of hydroxylsafflower yellow pigment A and paeoniflorin in 8 hours after mixing. Conclusions:The mixture are stable in 8 hours after Xuebijing injection combined with sodium aescinate for injection and Xuesaitong for injection, respectively.
出处
《天津药学》
2017年第6期6-10,共5页
Tianjin Pharmacy
