羚羊角胶囊治疗小儿复杂性热性惊厥临床疗效及安全性分析

Analysis of clinical effect and safety of Lingyangjiao Capsule in treating of complex febrile convulsion in children

目的观察羚羊角胶囊治疗小儿复杂性热性惊厥的临床疗效及其安全性。方法将2014年7月至2016年7月我院收治的61例复杂性热性惊厥患儿随机分为对照组和治疗组,对照组给予常规治疗,治疗组在对照组治疗方法的基础上加服羚羊角胶囊,观察、记录、分析2组的体温、抽搐情况及治疗过程中的不良反应。结果对照组再次发热的时间为(4.16±4.11)h,治疗组为(7.49±1.91)h,2组比较差异有统计学意义(P<0.05);对照组24 h内再次出现抽搐8例,治疗组出现抽搐2例,2组比较差异有统计学意义(P<0.05);随访1年后,对照组热性惊厥复发率为25.80%,治疗组为6.67%,2组比较差异有统计学意义(P<0.05);对照组与治疗组不良反应发生率分别为12.9%和20.0%,差异无统计学意义(P>0.05)。结论羚羊角胶囊对小儿复杂性热性惊厥有较好的疗效,且无明显的不良反应,患儿无禁忌证情况下可推广此疗法。

Objective To observe clinical effect and safety complex febrile convulsion. Methods 61 cases of children with of Lingyangjiao Capsule in treating of children with complex febrile convulsion from Jul. 2014 to Jul. 2016 were randomly divided into control group and therapy group. The control group was given conventional thera-py,while the therapy group was given Lingyangjiao Capsule based on the treatment of control group. And then ob- served, recorded and analyzed untoward effect, temperature and convulsion of patients in two groups. Results The time of fever again was （4.16_＋4.11 ） h in control group and（7.49_＋1.91 ） h in therapy group,there were signifi- cant differences in two groups （ P〈0.05 ） ; in 24 hours, 8 patients of control group and 2 of therapy group were in convulsion, differences had significance （ P〈0.05 ） ; after follow-up visited 1 year, the recurrence rate in control group and therapy group was 25.80% and 6.67% respectively with significant differences （ P〈0.05 ） ; the untoward effect in control group and therapy group was 12.9% and 20.0% respectively,which had no significant differences （P〉0.05）. Conclusion Lingyangjiao Capsule can treat children with complex febrile convulsion effectively and no obvious untoward effect. If patients have no contraindications, it is worthy of clinical promotion and application.