甲基化和乙酰化修饰在肿瘤发生发展中的作用

The roles of methylation and acetylation in tumorigenesis and development

表观遗传调控是目前国内外研究的热点,其已成为设计治疗多种疾病靶点的重要理论依据。本课题组以表观遗传调控研究为主要脉络,围绕肿瘤中异常的生物学过程,如DNA损伤应答与修复、细胞自噬和代谢等,初步阐明了蛋白质翻译后修饰中的甲基化和乙酰化及其相关的酶类在肿瘤发生发展中的作用及分子机制。现对本课题组的主要原创性工作进行综述与汇报。

The study of epigenetic regulation is the focus of biological related research worldwide, and has become an important theoretical basis for the design of targets for treatment of various diseases. We focused on the epigenetic regulation of abnormal biological processes in tumor, such as DNA damage response and repair, cellular autophagy and metabolism. Our studies reveal the roles and molecular mechanisms of methylation and acetylation, and related regulatory enzymes in tumorigenesis and cancer development. This review attempts to summarize our major original findings and discuss the future trends in this area.