降压调脂在社区治疗老年人高血压合并高脂血症的临床疗效

Clinical efficacy of antihypertensive and lipid-lowering therapy in the treatment of in senile patients with hypertension and hyperlipidemia

目的分析降压调脂在社区治疗老年人高血压合并高脂血症的临床疗效。方法 70例社区卫生服务站老年高血压合并高脂血症患者,随机分为观察组与对照组,每组35例。观察组给予氨氯地平阿托伐他汀钙联合辛伐他汀治疗,对照组给予氨氯地平或卡托普利治疗。对比两组治疗前后收缩压、舒张压、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平及心脑血管事件发生情况。结果治疗前两组血压及血脂水平比较差异均无统计学意义(P>0.05);治疗后两组收缩压及舒张压均较治疗前明显降低,且观察组降低幅度大于对照组,差异均具有统计学意义(P<0.05);治疗后观察组TG、TC、LDL-C较治疗前明显降低,HDL-C较治疗前明显升高,且观察组TG、TC、LDL-C明显低于对照组,HDL-C明显高于对照组,差异均具有统计学意义(P<0.05)。观察组心脑血管事件发生率为2.86%,低于对照组的17.14%,差异具有统计学意义(P<0.05)。结论降压调脂用于社区老年人高血压合并高脂血症中能改善患者血压和血脂水平,降低心脑血管事件发生率,值得推广。

Objective To analyze the clinical efficacy of antihypertensive and lipid-lowering therapy in the treatment of hypertension in senile patients with hyperlipidemia. Methods A total of 70 senile patients with hypertension and hyperlipidemia in Community Health Station were randomly divided into observation group and control group, with 35 cases in each group. The observation group was treated with amlodipine atorvastatin calcium combined with simvastatin, and the control group was treated with amlodipine or captopril. Comparison were made on systolic blood pressure, diastolic blood pressure, triglyceride（TG）, total cholesterol（TC）, low density lipoprotein cholesterol（LDL-C）, high density lipoprotein cholesterol（HDL-C） levels before and after treatment and the condition of cardio cerebrovascular events between two groups. Results Before treatment, both groups had no statistically significant difference in blood pressure and blood lipid level（P〉0.05）. After treatment, both groups had obviously lower systolic blood pressure and diastolic blood pressure than before treatment, and the observation group had larger decline degree than the control group. Their difference was statistically significant（P〈0.05）. After treatment, the observation group had obviously lower TG, TC and LDL-C than before treatment, and obviously higher HDL-C than before treatment. The observation group had obviously lower TG, TC, LDL-C and obviously higher HDL-C than the control group. Their difference was statistically significant（P〈0.05）. The observation group had lower incidence of cardio cerebrovascular events as 2.86% than 17.14% in the control group, and the difference was statistically significant（P〈0.05）. Conclusion Application of antihypertensive and lipid-lowering therapy in senile patients with hypertension and hyperlipidemia can improve the blood pressure and lipid level and lower incidence of cardio cerebrovascular events, and it is worthy of promotion.