多巴胺治疗新生儿窒息并心肾损害的临床研究

Clinical study of dopamine in the treatment of neonatal asphyxia complicated with heart and kidney damage

目的对多巴胺治疗新生儿窒息并心肾损害的临床治疗效果进行观察研究。方法 80例新生儿窒息并心肾损害患儿,随机分为对照组和观察组,每组40例。对照组患儿给予常规治疗,观察组患儿在对照组基础上给予多巴胺治疗。比较两组患儿治疗前后血液中血尿素氮(BUN)、肌酐(Cr)含量和血清中的心肌肌钙蛋白I(c Tn I)、肌酸激酶同工酶(CK-MB)浓度以及治疗效果。结果治疗前,两组患儿血液中BUN、Cr含量比较差异无统计学意义(P>0.05);治疗后,两组患儿血液中的BUN、Cr含量均较本组治疗前下降,且观察组下降幅度大于对照组,差异具有统计学意义(P<0.05)。治疗前,两组患儿血清中c Tn I、CK-MB浓度比较差异无统计学意义(P>0.05);治疗后,两组患儿血清中c Tn I、CK-MB浓度均较本组治疗前下降,且观察组下降幅度大于对照组,差异具有统计学意义(P<0.05)。观察组患儿治疗总有效率为97.5%,显著高于对照组的75.0%,差异具有统计学意义(P<0.05)。结论在常规治疗新生儿窒息并心肾损害患儿的基础上辅以多巴胺治疗,可以有效提高患儿的治疗效果,大大降低了患儿致残率和死亡率,值得进行临床推广。

Objective To observe and study the clinical treatment effect of dopamine in the treatment of neonatal asphyxia complicated with heart and kidney damage. Methods A total of 80 children with neonatal asphyxia and heart and kidney damage were randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with conventional therapy, and the observation group was treated with dopamine on the basis of the control group. Comparison were made on levels of blood urea nitrogen （BUN）, creatinine （Cr）, serum cardiac troponin I （cTnI）, ereatine kinase isoenzyme （CK-MB） concentration before and after treatment and the therapeutic effect between two groups. Results Before treatment, both groups had no statistically significant difference in concentrations of BUN and Cr in the blood （P〉0.05）. After treatment, both groups had lower concentrations of BUN and Cr in the blood than before treatment, and the observation group had greater decline degree than the control group. Their difference was statistically significant （P〈O.05）. Before treatment, both groups had no statistically significant difference in concentrations of cTnI and CK-MB in serum （/〉〉0.05）. After treatment, both groups had lower concentrations of cTnI and CK-MB in serum than before treatment, and the observation group had greater decline degree than the control group. Their difference was statistically significant （P〈0.05）. The observation group had obviously higher total treatment effective rate as 97.5% than 75.0% in the control group, and the difference was statistically significant （P〈0.05）. Conclusion On the basis of conventional therapy, dopamine can can effectively improve the treatment effect of children with neonatal asphyxia and heart and kidney damage, greatly reduce the morbidity and mortality of children. It is worthy of clinical promotion.