阿司匹林、替格瑞洛联合应用在不稳定型心绞痛治疗中的效果探讨

Discussion on effect of aspirin combined with ticagrelor in the treatment of unstable angina pectoris

目的分析阿司匹林、替格瑞洛联合应用在不稳定型心绞痛治疗中的效果。方法 77例不稳定型心绞痛患者,采用随机数字表法分为对照组(39例)及观察组(38例)。对照组应用阿司匹林+氯吡格雷治疗,观察组应用阿司匹林+替格瑞洛治疗。比较两组的治疗有效性和安全性。结果观察组的总有效率为94.74%,高于对照组的79.49%,差异具有统计学意义(χ~2=3.961,P=0.047<0.05)。观察组的不良反应发生率为7.89%,与对照组的5.13%比较差异无统计学意义(χ~2=0.243,P=0.622>0.05)。随访6个月,观察组的心血管事件发生率为5.26%,低于对照组的23.08%,差异具有统计学意义(χ~2=4.988,P=0.026<0.05)。结论联合应用阿司匹林、替格瑞洛治疗不稳定型心绞痛具有一定的疗效和安全性,且能够有效减少心血管事件的发生,对改善患者预后具有积极的临床意义。

Objective To analyze the effect of aspirin combined with ticagrelor in the treatment of unstable angina pectoris. Methods A total of 77 patients with unstable angina pectoris were divided by random number table method into control group （39 cases） and observation group （38 cases）. The control group was treated with aspirin ＋ elopidogrel, and the observation group was treated with aspirin ＋ ticagrelor. Comparison were made on treatment effectiveness and safety in two groups. Results The observation group had higher total effective rate as 94.74% than 79.49% in the control group, and the difference was statistically significant （χ2=3.961, P=0.047〈0.05）. The observation group had no statistically significant difference in incidence of adverse reactions as 7.89%, comparing with 5.13% in the control group （χ2-=0.243, P=0.622〉0.05）. After 6 months of folllow-up, the observation group had lower incidence of cardiovascular events as 5.26% than 23.08% in the control group, and the difference was statistically significant （χ2=4.988, P=0,026〈0.05）. Conclusion Combination of aspirin and ticagrelor has certain efficacy and safety in the treatment of unstable angina pectoris, and can effectively reduce the incidence of cardiovascular events. It has a positive clinical significance to improve the prognosis of patients.