低分子肝素钠联合低剂量黄体酮治疗先兆流产的临床观察

Clinical observation of low molecular weight heparin combined with low dose progesterone for treating pregnant women with threatened abortion

目的:观察低分子肝素钠与低剂量黄体酮联合治疗先兆流产的临床疗效。方法:以150例先兆流产患者为研究对象,随机分为观察组和对照组各75例。对照组予以常规剂量黄体酮治疗,观察组予以低剂量黄体酮并联合低分子肝素钠治疗。结果:观察组阴道止血时间、腹痛缓解时间和腰酸缓解时间均短于对照组(均P<0.05);治疗期间不良反应发生率(5.3%)低于对照组(16.0%)(P<0.05),新生儿体重和分娩时妊娠天数均大于对照组(均P<0.05)。两组新生儿畸形率未见差异(P>0.05)。结论:较常规剂量黄体酮治疗,低分子肝素钠联合低剂量黄体酮用以治疗先兆流产,可以减少患者的阴道出血时间、腹痛缓解时间和腰痛缓解时间,提高先兆流产治疗效果,降低药物不良反应,具有更好的用药安全性和有效性。

Objective：To observe the clinical efficacy of low molecular weight heparin sodium combined with low dose progesterone for treating pregnant women with threatened abortion.Methods：150 pregnant women with threatened abortion were randomly divided into study group and control group（75 cases in each group）.The pregnant women in control group were treated by routine dose of progesterone,and the pregnant women in study group were treated by low doses of progesterone combined with low molecular heparin.Results：The time of bleeding stop,and time of abdominal and backache pain remission of women in study group were significantly shorter than those of women in control group,（P〈0.05）.The incidence of adverse effect of women（5.3%）in study group was significant lower than that of women（16%）in control group（P〈0.05）.Birth weight of newborn and gestational days before birth were significant greater than those of women in the control group（P〈0.05）.Malformation rate of newborn had no significant difference between the two groups（P〉0.05）.Conclusion：Compared to the conventional dose of progesterone treatment,low molecular weight heparin combined with low doses of progesterone can significantly reduce the bleeding time and abdominal pain relief time,can improve the therapeutic effectiveness for treating threatened abortion,can reduce rate of adverse effect of drugs,and has better safety and effectiveness of drugs.