急性期精神分裂症患者阴性症状与血清叶酸、维生素B_(12)的相关性研究

A related study of negative symptoms and levels of serum folic acid,vitamin B_(12) in patients with schizophrenia

目的探讨急性期精神分裂症患者中阴性症状严重程度与血清中叶酸、维生素B_(12)水平的相关性。方法选取60例急性期精神分裂症住院患者,采用阳性和阴性综合征量表(PANSS)、阴性症状评定量表(SANS)、愉快情绪体验量表(TEPS)、躯体快感缺乏量表中文版(RPAS-C)评估,并测定血清叶酸、维生素B_(12)水平。结果相关性分析显示,入组患者的血清叶酸水平与RPAS-C总分呈负相关(P<0.05)。非吸烟患者的血清叶酸水平和TEPS总分呈负相关(P<0.05)。结论急性期精神分裂症患者的血清叶酸水平可能与阴性症状有关。

Objective To explore the correlation between negative symptoms and the levels of serum folic acid, vitamin B12 in patients with schizophrenia. Methods A total of 6 0 patients with schizophrenia were selected. They were assessed with Positive and Negative Syndrome Scale （ PANSS） , Scale for the Assessment of Negative Symptoms （SANS） , Temporal Experience of Pleasure Scale（TEPS）,Revised Physical Anhedonia Scale for Chinese（ RPAS-C） and examined with levels of serum folic acid and vitamin B12. Results In all patients,the level of serum folic acid was negatively correlated with the total score of RPAS-C （P 〈0. 05）. In non-smoking patients, the level of serum folic acid was negatively correlated with the total score of TEPS（P 〈0. 05） . Conclusion There is correlation between the negati schizophrenia.symptoms and the level of serum folic acid in patients with schizophrenia.