右美托咪定对腹腔镜手术患者围手术期血液动力学、镇痛效果及安全性研究

Perioperative hemodynamics and analgesic effect and safety of dexmedetomidine in laparoscopic surgery

目的研究右美托咪定对腹腔镜手术患者围手术期血流动力学以及术后镇静评分的影响。方法 112例行腹腔镜手术患者随机平均分为研究组和对照组,对照组患者注射生理盐水,研究组注射右美托咪定,比较两组患者的麻醉效果及安全性。结果围手术期研究组患者血流动力学指标的控制更好,术后24 h的镇痛效果更佳,平均镇痛时间和剂量更少,且两组患者的不良反应之间的差异无统计学意义(P>0.05)。结论右美托咪定的使用可延长术后无痛期,降低总止痛需求,是腹腔镜手术中理想的麻醉辅助剂。

Objective To study the effect of dexmedetomidine on perioperative hemodynamics parameters and postoper- ative sedation score in patients undergoing laparoseopic surgery. Methods A total of 112 patients underwent laparo- scopic surgery were randomly average divided into study group and control group. Patients in the control group injected with saline, the study group given dexmedetomidine injected, the anesthesia effect and safety of the two groups of pa- tients were compared. Results During the perioperative period, the study group had better control of hemodynamic pa- rameters, the analgesic effect was better 24 h after operation, the average analgesic time and dose were less, there was no statistically significant difference between the two groups in adverse reactions（P〉0.05）. Conclusion The use of dexmedetomidine extends the postoperative painless period, reducing the total analgesic demand. It is an ideal anesthe- sia adjuvant in laparoscopie surgery.