合肥地区输入性疟疾患者血液指标变化

The changes and diagnosis value of the blood index in imported malaria patients in Hefei areas

目的观察输入性疟疾患者实验室检测指标的变化情况,为临床诊断、治疗和预后判断情况提供参考。方法回顾性分析80例确诊为输入性疟疾感染患者的血常规、生化指标结果,并与100例健康体检人员进行对照分析。采用多因素二元Logistic逐步回归分析,完成对输入性疟疾检验参数指标的分析。并对80例输入性疟疾不同虫种之间实验室检测结果进行对比。结果与健康对照组相比,疟疾组的白细胞(WBC)、嗜酸性粒细胞百分比(E%)、红细胞(RBC)、血红蛋白(HB)、血小板(PLT)、总蛋白(TP)和尿酸(UA)降低,而中性粒细胞百分比(N%)、嗜碱性粒细胞百分比(B%)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TB)、直接胆红素(DB)、间接胆红素(IB)、尿素氮(BUN)以及肌酐(CR)升高,且差异均有统计学意义(P<0.05);二元Logistic逐步回归分析显示,N%、ALT、TB越高,患疟疾的可能性越大;HB、PLT越低,患疟疾的可能性也越大。疟疾不同虫种之间实验室指标差异无统计学意义。结论 N%、ALT、TB、HB、PLT可作为早期辅助诊断输入性疟疾的重要指标。

Objective To observe the changes of laboratory test indexes in patients with imported malaria, and provide scientific reference for clinical diagnosis, treatment and prognosis. Methods The routine blood test and biochemical indexes of 80 patients with imported malaria infection were collected and compared with those of 100 healthy persons using muhiple Logistic regression. The laboratory test results of imported malaria were compared with those of different species. Results Compared with the healthy control group, the levels of white blood cell （WBC） , eosinophil percentage （E%） , red blood cell （ RBC ） , hemoglobin （ HB ） , platelet （PLT） , total protein （TP） and uric acid （ UA ） in the malaria group were decreased, while neutrophilic granulocyte percentage （G%）, basophils percentage （B%）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, total hiliruhin （TB）, direct bilirubin （DB）, indirect biliruhin （IB）, blood urea nitrogen （BUN） and creatinine （CR） were increased, and there were statistical differences （P〈0.05）. Binary logistic stepwise regression analysis showed that the higher the N%, ALT and TB, the greater the possibility of malaria ; the lower the HB and PLT, the greater the possibility of malaria. Conclusions N%, ALT, TB, HB and PLT can he used as important indicator for early diagnosis of imported malaria.