HBV-X蛋白与肝细胞癌关系的研究进展

Advances in the study of the relationship between HBV-X protein and hepatocellular carcinoma

乙型肝炎病毒(HBV)感染引起急性或慢性肝炎,可导致肝衰竭、肝硬化,甚至发展成为肝细胞癌(HCC),其中病毒X基因表达的蛋白HBx在肝癌的发生发展和转移中起重要作用。本文主要针对目前HBx在HCC的发生、进展、转移以及潜在治疗效果等方面进行阐述。

Hepatitis B virus （HBV） infection causes acute or chronic hepatitis, and also leads to liver failure, cirrhosis, and even the development of hepatocellular carcinoma （HCC）. Protein HBx of the HBV- X gene plays a role in the occurrence and development and metastasis of liver cancer. This article focuses on the advance studies of the role of HBx in the occurrence, development and metastasis of HCC, and as drug target for treating HCC.