罕见部位脂肪肉瘤的诊断及文献复习

Diagnosis of liposarcoma in rare part and literature review

目的:分析6例罕见部位脂肪肉瘤的临床病理特征以提高诊断认识。方法:常规HE染色分析肿瘤形态,免疫组织化学方法分析肿瘤细胞分化方向。结果:6例均可见多少不等脂肪母细胞及不同分化程度的脂肪细胞,部分黏液变或纤维硬化。免疫组织化学周期依赖性蛋白激酶4(cyclindependent kinases,CDK4),MDM2及S-100阳性。结论:罕见部位的脂肪肉瘤结合病史、形态及组织化学等并不难诊断,关键在于不要受常规诊断思路局限,才能避免误诊。

Objective： To improve diagnosis by the Methods： The morphology of tumor was analysis of the clinicopathologic characteristics of 6 liposarcoma cases analyzed by routine HE staining, and the differentiation of tumor cells was analyzed by immunohistochemical method. Results： We saw some lipoblasts and differential lypocytes in the 6 cases, some of which showed mucoid degeneration and fibrosis. Cyclin-dependent kinases （CDK4）, MDM2 and S-100 were positive in tumor cells. Conclusion： It is not difficult to diagnosis liposarcoma in rare site, combined with history, morphology and histochemistry, etc. It is crucial that we should not be limited by conventional diagnostic thinking and then misdiagnosis can be avoided